Antidiarrheal Efficacy and Cellular Mechanisms of a Thai Herbal Remedy

• Published in: PLoS neglected tropical diseases Vol. 8; no. 2; p. e2674
• Main Authors: Tradtrantip, Lukmanee, Ko, Eun-A, Verkman, Alan S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2014; Public Library of Science (PLoS)
• Subjects: Animals; Antidiarrheals; Antidiarrheals - pharmacology; Antidiarrheals - therapeutic use; Biology; Care and treatment; Chloride Channels - antagonists & inhibitors; Chloride Channels - drug effects; Cholera; Cystic fibrosis; Diarrhea - drug therapy; Disease Models, Animal; Drug therapy; Eugenol; Gastrointestinal Motility - drug effects; Health aspects; Herbal medicine; Medicine; Medicine, Botanic; Medicine, Herbal; Mice; Mortality; Motility; Muscular system; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rodents; Rotavirus; Rotavirus Infections; Smooth muscle; Thailand; Thailand; Gastrointestinal Motility; Rotavirus Infections; Animals; Chloride Channels; Antidiarrheals; Plant Extracts; Diarrhea; Cholera; Mice; Thailand; Disease Models, Animal

Screening of herbal remedies for Cl(-) channel inhibition identified Krisanaklan, a herbal extract used in Thailand for treatment of diarrhea, as an effective antidiarrheal in mouse models of secretory diarrheas with inhibition activity against three Cl(-) channel targets. Krisanaklan fully inhibite...