LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

• Published in: Journal of hematology and oncology Vol. 9; no. 1; p. 117
• Main Authors: Wang, Wen-Tao, Ye, Hua, Wei, Pan-Pan, Han, Bo-Wei, He, Bo, Chen, Zhen- Hua, Chen, Yue-Qin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.11.2016; BMC
• Subjects: Biomarkers; Cell adhesion & migration; Cell cycle; Cell Line, Tumor; Cell Movement; ceRNA; Cholangiocarcinoma; Cholangiocarcinoma - etiology; Cholangiocarcinoma - genetics; Cholangiocarcinoma - pathology; Disease; Disease Progression; Hematology; Humans; Inflammation; Inflammation response; Interleukin-6 - genetics; MicroRNAs; Migration and invasion; Neoplasm Invasiveness; Oncology; Oxidative stress; Oxidative Stress - genetics; Pathogenesis; Proteins; Receptors, CXCR4 - genetics; RNA, Long Noncoding - metabolism; RNA, Long Noncoding - physiology; United States > US; China; Japan; Oxidative stress; ceRNA; Migration and invasion; Cholangiocarcinoma; Inflammation response

Long non-coding RNAs (lncRNAs) are known to play important roles in different cell contexts, including cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis, associated with chronic inflammation and damage to the biliary epitheliu...