Infections associated with haemophagocytic syndrome

• Published in: The Lancet infectious diseases Vol. 7; no. 12; pp. 814 - 822
• Main Authors: Rouphael, Nadine G, Dr, Talati, Naasha J, MD, Vaughan, Camille, MD, Cunningham, Kelly, MD, Moreira, Roger, MD, Gould, Carolyn, MD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: London Elsevier Ltd 01.12.2007; Lancet Publishing Group; Elsevier Limited
• Subjects: Abdomen; Adult; Biological and medical sciences; Diagnosis, Differential; DNA, Viral - analysis; Epstein-Barr Virus Infections - blood; Epstein-Barr Virus Infections - diagnosis; Fatal Outcome; Female; Fingers - abnormalities; Gastroenterology. Liver. Pancreas. Abdomen; Heart Septal Defects; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - isolation & purification; Human viral diseases; Humans; Infectious Disease; Infectious diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Lymphocytes; Lymphohistiocytosis, Hemophagocytic - blood; Lymphohistiocytosis, Hemophagocytic - diagnosis; Medical sciences; Other diseases. Semiology; Polymerase Chain Reaction; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Splenomegaly; Liver; Splenic disease; Hepatic disease; Autoimmune disease; Hemopathy; Epstein Barr virus; Hepatitis; Hemophagocytic lymphohistiocytosis; Hepatomegaly; Rare disease; Gammaherpesvirinae; Immunopathology; Parvovirus; Herpesviridae; Retroviridae; Herpes; Malignant tumor; Histiocytosis; Lentivirus; Fever; Infection; Virus; Hemophagocytic syndrome; Treatment; Parvoviridae; Viral disease; Influenza; Bacteriosis; Digestive diseases; Human immunodeficiency virus; Cancer; Parvovirinae

Summary Haemophagocytic syndrome or haemophagocytic lymphohistiocytosis is a rare disease that is often fatal despite treatment. Haemophagocytic syndrome is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of lymphocytes or histiocytes with uncon...