Neutrophil Extracellular Traps Identification in Tegumentary Lesions of Patients with Paracoccidioidomycosis and Different Patterns of NETs Generation In Vitro

• Published in: PLoS neglected tropical diseases Vol. 9; no. 9; p. e0004037
• Main Authors: Della Coletta, Amanda Manoel, Bachiega, Tatiana Fernanda, de Quaglia e Silva, Juliana Carvalho, Soares, Ângela Maria Victoriano de Campos, De Faveri, Julio, Marques, Silvio Alencar, Marques, Mariângela Esther Alencar, Ximenes, Valdecir Farias, Dias-Melicio, Luciane Alarcão
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2015; Public Library of Science (PLoS)
• Subjects: Aged; Brazil; Development and progression; Extracellular matrix; Extracellular Traps - metabolism; Fungal infections; Genetic aspects; Humans; Immune response; Male; Microscopy, Confocal; Middle Aged; Neutrophils; Neutrophils - immunology; Observations; Paracoccidioides; Paracoccidioides - immunology; Paracoccidioides brasiliensis; Paracoccidioidomycosis; Paracoccidioidomycosis - immunology; Paracoccidioidomycosis - pathology; Pathology; Properties; Prospective Studies; Respiratory distress syndrome; Spectrum Analysis; Studies; Brazil

Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in most Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus of the genus Paracoccidioides (Paracoccidioides brasiliensis and Paracoccidioides lutzii). Innate immune response plays a crucial role in ho...