Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers

• Published in: AIDS research and therapy Vol. 21; no. 1; pp. 71 - 9
• Main Authors: Sato, Wakana, Sedohara, Ayako, Koga, Michiko, Nakagama, Yu, Yotsuyanagi, Hiroshi, Kido, Yasutoshi, Adachi, Eisuke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.10.2024; BioMed Central; BMC
• Subjects: Adult; Analysis; Asymptomatic; Bacteremia; Bacteremia - epidemiology; Bacteremia - microbiology; Bejel; Biological analysis; Biomarkers; Biomarkers - blood; Blood; Blood circulation; C-reactive protein; Disease transmission; Epidemics; Epidemiology; Genomes; Genotype; Health aspects; HIV; HIV Infections - epidemiology; HIV Infections - microbiology; Homosexuality, Male; Human immunodeficiency virus; Humans; Japan - epidemiology; Laboratories; Male; Maximum likelihood method; Middle Aged; Molecular Epidemiology; MSM (Men who have sex with men); Multi-locus sequence typing; Multilocus Sequence Typing; Phylogenetics; Phylogeny; Prevention; Psychological aspects; Serology; Sexually transmitted diseases; Social aspects; STD; Syphilis; Syphilis - epidemiology; Syphilis - microbiology; Treponema pallidum; Treponema pallidum - classification; Treponema pallidum - genetics; Treponema pallidum subsp. endemicum; Treponema pallidum subspecies pallidum; Japan; Germany; Syphilis; Treponema pallidum subspecies pallidum; Multi-locus sequence typing; Treponema pallidum subsp. endemicum; Bejel

The challenges in culturing Treponema pallidum have hindered molecular-biological analysis. This study aims to establish a molecular epidemiological analysis of syphilis among Japanese men who have sex with men (MSM) and to investigate the relationship between bacteremia and associated pathophysiolo...