PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

• Published in: Molecular neurodegeneration Vol. 15; no. 1; pp. 20 - 18
• Main Authors: Ge, Preston, Dawson, Valina L., Dawson, Ted M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.03.2020; BioMed Central; BMC
• Subjects: Animals; Bioenergetics; Brain; Cell death; Cell division; Central nervous system; Development and progression; Disease susceptibility; Diseases; Dopamine; Energy Metabolism - physiology; Genes; Genomes; Humans; Metabolism; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial DNA; Mitophagy; Movement disorders; Mutation; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurons; Neurons - metabolism; Neurons - pathology; Parkin; Parkin protein; Parkinson disease; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Pathogenesis; Pathology; Phenols (Class of compounds); Phosphorylation; PINK1; Protein Kinases - genetics; Protein Kinases - metabolism; Proteins; PTEN-induced putative kinase; Quality control; Review; Selective vulnerability; Specialization; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; France; Mitochondria; PINK1; Substantia nigra; Parkinson disease; Selective vulnerability; Mitophagy; Parkin

That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulations, including dopamine neurons in the substantia nigra pars compacta, have a shared phenotyp...