A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma

• Published in: BMC cancer Vol. 24; no. 1; pp. 14 - 17
• Main Authors: Ai, Jiaoyu, Zhang, Wanlin, Deng, Wensheng, Yan, Likun, Zhang, Lidong, Huang, Zongjing, Wu, Ziyi, Ai, Junhua, Jiang, Hai
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.01.2024; BioMed Central; BMC
• Subjects: Analysis; Animal models; Animals; Apoptosis; Bioinformatics; Biomarkers; Carcinoma, Hepatocellular - genetics; Care and treatment; Cell Line, Tumor; Cell migration; Cell proliferation; Cell Proliferation - genetics; Circular RNA; Development and progression; Disease Models, Animal; E2F6; E2F6 Transcription Factor; Fluorescence; Fluorescence in situ hybridization; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Gene therapy; Genes; Genetic aspects; Health savings accounts; Hepatocellular carcinoma; Hepatoma; Hsa_circ_001726; Humans; Immunoprecipitation; In Situ Hybridization, Fluorescence; Liver cancer; Liver Neoplasms - genetics; Luciferase; Lung cancer; Medical prognosis; Metastases; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; Patient outcomes; Phenotypes; Prevention; PRMT9; Proteins; Reagents; Risk factors; RNA; RNA, Circular - genetics; Signal transduction; Stem cells; Surgery; Transplantation; Tumors; Western blotting; Wound healing; Xenografts; China; United States > US; Hepatocellular carcinoma; Hsa_circ_001726; Metastasis; E2F6; PRMT9

CircRNAs participate in the development of hepatocellular carcinoma (HCC). This work aims to explore the key tumor promoting circRNA as a gene therapy target. The differentially expressed gene circRNAs in HCC tumor tissues was identified by mining GSE121714 dataset. EdU staining, wound healing, tran...