Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase - Tokuda, Eiichi; Brännström, Thomas; Andersen, Peter M.; Marklund, Stefan L. (Acta neuropathologica communications, 2016)
Keywords: Adult; Aged; Aged, 80 and over; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - pathology; Animals; Apoptosis Regulatory Proteins - deficiency; Apoptosis Regulatory Proteins - genetics; Autophagy; Autophagy (Cytology); Autophagy - genetics; Beclin-1; C9orf72 Protein; Disease Models, Animal; Female; Gene expression; Gene Expression Regulation - genetics; Genetic aspects; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Motor ability; Motor system vulnerability; Mutation - genetics; Parkinson Disease - genetics; Parkinson Disease - pathology; Phenotype; Physiological aspects; Properties; Proteasome Endopeptidase Complex - metabolism; Protein aggregates; Protein Aggregation, Pathological - genetics; Proteins - genetics; Spinal Cord - metabolism; Spinal Cord - pathology; Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide sumutase-1; Ubiquitinated Proteins - genetics; Ubiquitinated Proteins - metabolism