Why and how to use the body's own stem cells for regeneration in musculoskeletal disorders: a primer

Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these...

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Published inJournal of orthopaedic surgery and research Vol. 17; no. 1; p. 36
Main Authors Furia, John P, Lundeen, Mark A, Hurd, Jason L, Pearce, David A, Alt, Christopher, Alt, Eckhard U, Schmitz, Christoph, Maffulli, Nicola
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 21.01.2022
BioMed Central
BMC
Subjects
Adipose Tissue
Adipose tissues
Adipose-derived regenerative cells
Adipose-derived stem cells
ADRCs
ADSCs
Autografts
Biopsy
Blood vessels
Body fat
Bone marrow
Bone Regeneration
Cartilage regeneration
Cell culture
Cell cycle
Cell- and Tissue-Based Therapy
Feasibility studies
Humans
Laboratories
Liposuction
Mesenchyme
Methods
Musculoskeletal diseases
Musculoskeletal Diseases - therapy
Musculoskeletal system
Orthopedics
Patients
Physical therapy
Physiology
Pluripotency
Pluripotent Stem Cells
Precision medicine
Regenerative Medicine
Stem Cell Transplantation
Stem cells
Steroids
Tendons
Transplantation, Autologous
Trauma
ADSCs
Bone regeneration
Tendon healing without scar formation
Adipose-derived regenerative cells
Stem cell
vaPS cells
Cartilage regeneration
Tendon regeneration
Efficacy
Adipose-derived stem cells
ADRCs
Point of care treatment
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Abstract Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient's body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which-albeit less efficiently-also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
AbstractList Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient's body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which--albeit less efficiently--also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
BACKGROUNDRecently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. METHODSBased on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. RESULTSThe ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient's body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). CONCLUSIONSThe use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which-albeit less efficiently-also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
Abstract Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Methods Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. Results The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient’s body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). Conclusions The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which—albeit less efficiently—also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Methods Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. Results The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient's body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). Conclusions The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which--albeit less efficiently--also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine. Keywords: Adipose-derived regenerative cells, ADRCs, Adipose-derived stem cells, ADSCs, Bone regeneration, Cartilage regeneration, Efficacy, Point of care treatment, Stem cell, Tendon healing without scar formation, Tendon regeneration, vaPS cells
Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Methods Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. Results The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient’s body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). Conclusions The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which—albeit less efficiently—also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
Abstract Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Methods Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. Results The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient’s body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). Conclusions The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which—albeit less efficiently—also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient's body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which-albeit less efficiently-also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.
ArticleNumber 36
Audience Academic
Author Furia, John P
Hurd, Jason L
Alt, Christopher
Maffulli, Nicola
Schmitz, Christoph
Alt, Eckhard U
Lundeen, Mark A
Pearce, David A
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  fullname: Lundeen, Mark A
  organization: Sanford Orthopedics & Sports Medicine Fargo, Fargo, ND, USA
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  surname: Hurd
  fullname: Hurd, Jason L
  organization: Sanford Orthopedics & Sports Medicine Sioux Falls, Sioux Falls, SD, USA
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  organization: Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
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  fullname: Alt, Christopher
  organization: Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80331, Munich, Germany
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  surname: Schmitz
  fullname: Schmitz, Christoph
  email: christoph_schmitz@med.uni-muenchen.de
  organization: Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80331, Munich, Germany. christoph_schmitz@med.uni-muenchen.de
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  givenname: Nicola
  surname: Maffulli
  fullname: Maffulli, Nicola
  organization: School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University School of Medicine, Stoke on Trent, England
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CitedBy_id crossref_primary_10_1097_JSA_0000000000000350
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Cites_doi 10.3390/cells9051097
10.1177/03635465211037343
10.1002/stem.2855
10.1186/s12967-018-1420-z
10.1002/jor.24307
10.4252/wjsc.v13.i7.944
10.1111/jdv.14489
10.1634/stemcells.2005-0234
10.1186/s13075-016-1195-7
10.1177/0363546516662455
10.3390/cells10092303
10.1093/bmb/ldv047
10.1007/s00167-013-2457-4
10.3727/096368915X686968
10.1111/wrr.12482
10.1161/CIRCULATIONAHA.110.955971
10.1089/ten.TEA.2018.0341
10.2174/1574888x10666151019120217
10.1056/NEJMc1402340
10.1371/journal.pone.0221457
10.1114/1.1616931
10.1186/s13287-017-0503-8
10.1093/bmb/ldz040
10.1016/j.arthro.2021.06.033
10.1186/s12967-020-02530-6
10.1080/14712598.2018.1424626
10.1016/j.knee.2019.07.017
10.1016/j.jse.2019.05.043
10.1007/s00774-019-01013-z
10.4252/wjsc.v11.i10.831
10.1016/j.jcyt.2018.11.003
10.1016/S0140-6736(17)31366-1
10.1002/sctm.18-0053
10.1002/jor.22853
10.20944/preprints202101.0138.v1
10.1016/j.arthro.2012.12.008
10.1186/s13018-020-01631-8
10.1007/s00441-015-2239-z
10.5435/JAAOSGlobal-D-20-00185
10.1093/bmb/ldab008
10.46582/jsrm.1601004
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Issue 1
Keywords ADSCs
Bone regeneration
Tendon healing without scar formation
Adipose-derived regenerative cells
Stem cell
vaPS cells
Cartilage regeneration
Tendon regeneration
Efficacy
Adipose-derived stem cells
ADRCs
Point of care treatment
Language English
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PublicationDate 2022-01-21
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PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-21
  day: 21
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Journal of orthopaedic surgery and research
PublicationTitleAlternate J Orthop Surg Res
PublicationYear 2022
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References PC Noback (2918_CR30) 2021; 5
PK Gupta (2918_CR37) 2016; 18
2918_CR8
2918_CR4
L Ruzzini (2918_CR5) 2014; 22
AJ Joswig (2918_CR49) 2017; 8
D Kuah (2918_CR38) 2018; 16
JA Dykstra (2918_CR18) 2020; 16
F Migliorini (2918_CR43) 2021; 138
P Avanzi (2918_CR45) 2019; 28
2918_CR25
2918_CR24
JS Song (2918_CR36) 2019; 26
JL Hurd (2918_CR20) 2020; 15
2918_CR26
KK Obana (2918_CR28) 2021
XP Huang (2918_CR48) 2010; 122
N Bhattacharya (2918_CR33) 2011; 90
JA van Dongen (2918_CR11) 2016; 24
I Andia (2918_CR9) 2018; 18
HS Chen (2918_CR17) 2015; 24
EU Alt (2918_CR1) 2021; 10
G Cossu (2918_CR16) 2018; 391
2918_CR12
E Nyberg (2918_CR14) 2019; 25
2918_CR50
GM Peretti (2918_CR40) 2018; 32
S KhalifehSoltani (2918_CR34) 2019; 21
BA Naaijkens (2918_CR27) 2015; 362
EU Alt (2918_CR2) 2020; 9
C Schmitz (2918_CR7) 2015; 116
PK Beredjiklian (2918_CR23) 2003; 31
H Tian (2918_CR3) 2016; 11
GE Winnier (2918_CR6) 2019; 14
G Reurink (2918_CR31) 2014; 370
LM Galatz (2918_CR22) 2015; 33
J Matas (2918_CR35) 2019; 8
SA Shapiro (2918_CR41) 2017; 45
JB Mitchell (2918_CR15) 2006; 24
A Haenel (2918_CR19) 2019; 11
DE Connor (2918_CR32) 2019; 37
P Sadovský (2918_CR46) 2005; 72
NB Condron (2918_CR29) 2021; 37
CH Jo (2918_CR39) 2018; 36
SS Polly (2918_CR13) 2019; 37
KY Saw (2918_CR44) 2013; 29
A Konstantinow (2918_CR10) 2017; 31
E Alt (2918_CR21) 2021; 13
JM Lamo-Espinosa (2918_CR42) 2020; 18
E Chisari (2918_CR47) 2020; 133
References_xml – volume: 9
  start-page: 1097
  issue: 5
  year: 2020
  ident: 2918_CR2
  publication-title: Cells
  doi: 10.3390/cells9051097
  contributor:
    fullname: EU Alt
– year: 2021
  ident: 2918_CR28
  publication-title: Am J Sports Med
  doi: 10.1177/03635465211037343
  contributor:
    fullname: KK Obana
– volume: 36
  start-page: 1441
  issue: 9
  year: 2018
  ident: 2918_CR39
  publication-title: Stem Cells
  doi: 10.1002/stem.2855
  contributor:
    fullname: CH Jo
– volume: 16
  start-page: 49
  issue: 1
  year: 2018
  ident: 2918_CR38
  publication-title: J Transl Med
  doi: 10.1186/s12967-018-1420-z
  contributor:
    fullname: D Kuah
– volume: 37
  start-page: 1429
  issue: 6
  year: 2019
  ident: 2918_CR13
  publication-title: J Orthop Res
  doi: 10.1002/jor.24307
  contributor:
    fullname: SS Polly
– volume: 13
  start-page: 944
  issue: 7
  year: 2021
  ident: 2918_CR21
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v13.i7.944
  contributor:
    fullname: E Alt
– volume: 32
  start-page: 193
  issue: 6 Suppl. 1
  year: 2018
  ident: 2918_CR40
  publication-title: J Biol Regul Homeost Agents
  contributor:
    fullname: GM Peretti
– ident: 2918_CR4
– volume: 31
  start-page: 2104
  issue: 12
  year: 2017
  ident: 2918_CR10
  publication-title: J Eur Acad Dermatol Venereol
  doi: 10.1111/jdv.14489
  contributor:
    fullname: A Konstantinow
– volume: 24
  start-page: 376
  issue: 2
  year: 2006
  ident: 2918_CR15
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0234
  contributor:
    fullname: JB Mitchell
– ident: 2918_CR24
– volume: 18
  start-page: 301
  issue: 1
  year: 2016
  ident: 2918_CR37
  publication-title: Arthritis Res Ther
  doi: 10.1186/s13075-016-1195-7
  contributor:
    fullname: PK Gupta
– volume: 45
  start-page: 82
  issue: 1
  year: 2017
  ident: 2918_CR41
  publication-title: Am J Sports Med
  doi: 10.1177/0363546516662455
  contributor:
    fullname: SA Shapiro
– volume: 10
  start-page: 2303
  issue: 9
  year: 2021
  ident: 2918_CR1
  publication-title: Cells
  doi: 10.3390/cells10092303
  contributor:
    fullname: EU Alt
– volume: 116
  start-page: 115
  issue: 1
  year: 2015
  ident: 2918_CR7
  publication-title: Br Med Bull
  doi: 10.1093/bmb/ldv047
  contributor:
    fullname: C Schmitz
– volume: 22
  start-page: 2856
  issue: 11
  year: 2014
  ident: 2918_CR5
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-013-2457-4
  contributor:
    fullname: L Ruzzini
– volume: 90
  start-page: 395
  year: 2011
  ident: 2918_CR33
  publication-title: Transplantation
  contributor:
    fullname: N Bhattacharya
– volume: 24
  start-page: 509
  issue: 3
  year: 2015
  ident: 2918_CR17
  publication-title: Cell Transplant
  doi: 10.3727/096368915X686968
  contributor:
    fullname: HS Chen
– volume: 24
  start-page: 994
  issue: 6
  year: 2016
  ident: 2918_CR11
  publication-title: Wound Repair Regen
  doi: 10.1111/wrr.12482
  contributor:
    fullname: JA van Dongen
– ident: 2918_CR12
– volume: 122
  start-page: 2419
  issue: 23
  year: 2010
  ident: 2918_CR48
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.110.955971
  contributor:
    fullname: XP Huang
– volume: 25
  start-page: 1459
  issue: 21–22
  year: 2019
  ident: 2918_CR14
  publication-title: Tissue Eng A
  doi: 10.1089/ten.TEA.2018.0341
  contributor:
    fullname: E Nyberg
– volume: 11
  start-page: 158
  issue: 2
  year: 2016
  ident: 2918_CR3
  publication-title: Curr Stem Cell Res Ther
  doi: 10.2174/1574888x10666151019120217
  contributor:
    fullname: H Tian
– volume: 370
  start-page: 2546
  issue: 26
  year: 2014
  ident: 2918_CR31
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc1402340
  contributor:
    fullname: G Reurink
– volume: 14
  start-page: e0221457
  issue: 9
  year: 2019
  ident: 2918_CR6
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0221457
  contributor:
    fullname: GE Winnier
– volume: 72
  start-page: 293
  issue: 5
  year: 2005
  ident: 2918_CR46
  publication-title: Acta Chir Orthop Traumatol Cech
  contributor:
    fullname: P Sadovský
– volume: 31
  start-page: 1143
  issue: 10
  year: 2003
  ident: 2918_CR23
  publication-title: Ann Biomed Eng
  doi: 10.1114/1.1616931
  contributor:
    fullname: PK Beredjiklian
– volume: 8
  start-page: 42
  issue: 1
  year: 2017
  ident: 2918_CR49
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-017-0503-8
  contributor:
    fullname: AJ Joswig
– ident: 2918_CR50
– volume: 133
  start-page: 49
  issue: 1
  year: 2020
  ident: 2918_CR47
  publication-title: Br Med Bull
  doi: 10.1093/bmb/ldz040
  contributor:
    fullname: E Chisari
– volume: 37
  start-page: 3200
  issue: 10
  year: 2021
  ident: 2918_CR29
  publication-title: Arthroscopy
  doi: 10.1016/j.arthro.2021.06.033
  contributor:
    fullname: NB Condron
– volume: 18
  start-page: 356
  issue: 1
  year: 2020
  ident: 2918_CR42
  publication-title: J Transl Med
  doi: 10.1186/s12967-020-02530-6
  contributor:
    fullname: JM Lamo-Espinosa
– volume: 18
  start-page: 389
  issue: 4
  year: 2018
  ident: 2918_CR9
  publication-title: Expert Opin Biol Ther
  doi: 10.1080/14712598.2018.1424626
  contributor:
    fullname: I Andia
– volume: 26
  start-page: 1445
  issue: 6
  year: 2019
  ident: 2918_CR36
  publication-title: Knee
  doi: 10.1016/j.knee.2019.07.017
  contributor:
    fullname: JS Song
– volume: 28
  start-page: 1918
  issue: 10
  year: 2019
  ident: 2918_CR45
  publication-title: J Shoulder Elbow Surg
  doi: 10.1016/j.jse.2019.05.043
  contributor:
    fullname: P Avanzi
– volume: 37
  start-page: 759
  issue: 5
  year: 2019
  ident: 2918_CR32
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-019-01013-z
  contributor:
    fullname: DE Connor
– ident: 2918_CR26
– volume: 11
  start-page: 831
  issue: 10
  year: 2019
  ident: 2918_CR19
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v11.i10.831
  contributor:
    fullname: A Haenel
– volume: 21
  start-page: 54
  issue: 1
  year: 2019
  ident: 2918_CR34
  publication-title: Cytotherapy
  doi: 10.1016/j.jcyt.2018.11.003
  contributor:
    fullname: S KhalifehSoltani
– volume: 391
  start-page: 883
  issue: 10123
  year: 2018
  ident: 2918_CR16
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31366-1
  contributor:
    fullname: G Cossu
– volume: 8
  start-page: 215
  issue: 3
  year: 2019
  ident: 2918_CR35
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.18-0053
  contributor:
    fullname: J Matas
– volume: 33
  start-page: 823
  issue: 6
  year: 2015
  ident: 2918_CR22
  publication-title: J Orthop Res
  doi: 10.1002/jor.22853
  contributor:
    fullname: LM Galatz
– ident: 2918_CR8
  doi: 10.20944/preprints202101.0138.v1
– volume: 29
  start-page: 684
  issue: 4
  year: 2013
  ident: 2918_CR44
  publication-title: Arthroscopy
  doi: 10.1016/j.arthro.2012.12.008
  contributor:
    fullname: KY Saw
– volume: 15
  start-page: 122
  issue: 1
  year: 2020
  ident: 2918_CR20
  publication-title: J Orthop Surg Res
  doi: 10.1186/s13018-020-01631-8
  contributor:
    fullname: JL Hurd
– ident: 2918_CR25
– volume: 362
  start-page: 623
  issue: 3
  year: 2015
  ident: 2918_CR27
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-015-2239-z
  contributor:
    fullname: BA Naaijkens
– volume: 5
  start-page: e20.00185
  issue: 1
  year: 2021
  ident: 2918_CR30
  publication-title: J Am Acad Orthop Surg Glob Res Rev
  doi: 10.5435/JAAOSGlobal-D-20-00185
  contributor:
    fullname: PC Noback
– volume: 138
  start-page: 144
  issue: 1
  year: 2021
  ident: 2918_CR43
  publication-title: Br Med Bull
  doi: 10.1093/bmb/ldab008
  contributor:
    fullname: F Migliorini
– volume: 16
  start-page: 16
  issue: 1
  year: 2020
  ident: 2918_CR18
  publication-title: J Stem Cells Regen Med.
  doi: 10.46582/jsrm.1601004
  contributor:
    fullname: JA Dykstra
SSID ssj0050584
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Snippet Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in...
Abstract Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels,...
Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can...
BACKGROUNDRecently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be...
Abstract Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels,...
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StartPage 36
SubjectTerms Adipose Tissue
Adipose tissues
Adipose-derived regenerative cells
Adipose-derived stem cells
ADRCs
ADSCs
Autografts
Biopsy
Blood vessels
Body fat
Bone marrow
Bone Regeneration
Cartilage regeneration
Cell culture
Cell cycle
Cell- and Tissue-Based Therapy
Feasibility studies
Humans
Laboratories
Liposuction
Mesenchyme
Methods
Musculoskeletal diseases
Musculoskeletal Diseases - therapy
Musculoskeletal system
Orthopedics
Patients
Physical therapy
Physiology
Pluripotency
Pluripotent Stem Cells
Precision medicine
Regenerative Medicine
Stem Cell Transplantation
Stem cells
Steroids
Tendons
Transplantation, Autologous
Trauma
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Title Why and how to use the body's own stem cells for regeneration in musculoskeletal disorders: a primer
URI https://www.ncbi.nlm.nih.gov/pubmed/35062984
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https://search.proquest.com/docview/2622282167
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