Detection of Serotype-Specific Antibodies to the Four Dengue Viruses Using an Immune Complex Binding (ICB) ELISA

• Published in: PLoS neglected tropical diseases Vol. 7; no. 12; p. e2580
• Main Authors: Emmerich, Petra, Mika, Angela, Schmitz, Herbert
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Antibodies; Antibodies, Viral - blood; Antigen-Antibody Complex - analysis; Antigens, Viral - genetics; Binding sites (Biochemistry); Clinical Laboratory Techniques - methods; Dengue - diagnosis; Dengue - immunology; Dengue fever; Dengue virus; Dengue Virus - immunology; Dengue viruses; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Enzymes; Female; Health aspects; Host-parasite relationships; Humans; Infections; Male; Methods; Middle Aged; Mortality; Physiological aspects; Recombinant Proteins - genetics; Time Factors; Vietnam; Viral antibodies; Virus research; Viruses; Young Adult; Vietnam; Germany; Antigen-Antibody Complex; Enzyme-Linked Immunosorbent Assay; Clinical Laboratory Techniques; Dengue; Humans; Middle Aged; Male; Recombinant Proteins; Antibodies, Viral; Dengue Virus; Young Adult; Vietnam; Antigens, Viral; Time Factors; Adolescent; Adult; Female

Dengue virus (DENV) infections are preferentially diagnosed by detection of specific IgM antibodies, DENV NS1 antigen assays or by amplification of viral RNA in serum samples of the patients. The type-specific immunity to the four worldwide circulating DENV serotypes can be determined by neutralizat...