Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

• Published in: Molecular neurodegeneration Vol. 15; no. 1; pp. 30 - 22
• Main Authors: Wang, Wenzhang, Zhao, Fanpeng, Ma, Xiaopin, Perry, George, Zhu, Xiongwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.05.2020; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - metabolism; Animals; Axonal transport; Bioenergetics; Biomarkers; Brain; Brain - metabolism; Cognitive ability; Dehydrogenases; Dementia; Development and progression; Disease; Energy; Glucose; Humans; Metabolism; Mitochondria; Mitochondria - metabolism; Mitochondrial dynamics; Mitochondrial dysfunction; mtDNA; Mutation; Nervous system; Neurodegenerative diseases; Neurons; Neurons - metabolism; Pathogenesis; Pathology; Phosphorylation; Physiology; Review; Senile plaques; Signal transduction; Structure-function relationships; Target marketing; Tau protein; tau Proteins - metabolism; Therapeutic applications; Mitochondrial biogenesis; Mitochondrial dysfunction; Alzheimer’s disease; Bioenergetics; ER-mitochondria association; mtDNA; Mitochondrial dynamics; Axonal transport; Mitochondrial proteostasis; Mitochondrial quality control

Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain. Under the microscope, neuronal accumulation of abnormal tau proteins and amyloid plaques are two pathological hallmarks in a...