Mechanism of RNA modification N6-methyladenosine in human cancer

• Published in: Molecular cancer Vol. 19; no. 1; pp. 104 - 20
• Main Authors: Zhou, Zijian, Lv, Jiancheng, Yu, Hao, Han, Jie, Yang, Xiao, Feng, Dexiang, Wu, Qikai, Yuan, Baorui, Lu, Qiang, Yang, Haiwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.06.2020; BioMed Central; BMC
• Subjects: Adenosine - analogs & derivatives; Adenosine - chemistry; Binding sites; Biomarkers, Tumor - genetics; Cancer; Cytoplasm; Development and progression; Disease Progression; DNA damage; DNA Methylation; Epigenesis, Genetic; Epigenetic inheritance; Gene expression; Genes; Genetic transcription; Genetic translation; Health aspects; Humans; Hypotheses; Leukemia; Mammals; Messenger RNA; Metabolism; Methylation; Methyltransferases; Methyltransferases - metabolism; MicroRNAs; Mutation; N6-methyladenosine; Neoplasms - genetics; Neoplasms - pathology; Post-transcription; Proteins; Review; RNA methylation; RNA modification; RNA processing; Transcriptomics; Transfer RNA; Tumorigenesis; Canada; N6-methyladenosine; RNA methylation; Cancer

Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic modification in eukaryotes mRNA, heralded the creation of the...