High Rate of Subclinical Chikungunya Virus Infection and Association of Neutralizing Antibody with Protection in a Prospective Cohort in The Philippines

• Published in: PLoS neglected tropical diseases Vol. 9; no. 5; p. e0003764
• Main Authors: Yoon, In-Kyu, Alera, Maria Theresa, Lago, Catherine B., Tac-An, Ilya A., Villa, Daisy, Fernandez, Stefan, Thaisomboonsuk, Butsaya, Klungthong, Chonticha, Levy, Jens W., Velasco, John Mark, Roque, Vito G., Salje, Henrik, Macareo, Louis R., Hermann, Laura L., Nisalak, Ananda, Srikiatkhachorn, Anon
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2015; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Asia; Asymptomatic Infections - epidemiology; Base Sequence; Care and treatment; Caribbean Region; Chikungunya fever; Chikungunya Fever - epidemiology; Chikungunya Fever - immunology; Chikungunya Fever - transmission; Chikungunya Fever - virology; Chikungunya virus; Chikungunya virus - immunology; Chikungunya virus - isolation & purification; Child; Child, Preschool; Cohort Studies; Confidence intervals; Distribution; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Genotype & phenotype; Health aspects; Humans; Illnesses; Immunoglobulin G - blood; Immunoglobulin M - blood; Infant; Infections; Longitudinal Studies; Male; Middle Aged; Mosquitoes; Neutralization Tests; Philippines - epidemiology; Phylogenetics; Phylogeny; Prospective Studies; Sequence Analysis, RNA; Studies; Surveillance; Young Adult; Asia; Philippines; Caribbean Region; ASW, Caribbean Sea; ISEW, Philippines

Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of subclinical and symptomatic CHIKV infections in a prospective cohort study in a countr...