Prognostic significance of multiparametric flow cytometry minimal residual disease at two time points after induction in pediatric acute myeloid leukemia

• Published in: BMC cancer Vol. 24; no. 1; pp. 46 - 14
• Main Authors: Zheng, Yongzhi, Pan, Lili, Li, Jian, Feng, Xiaoqin, Li, Chunfu, Zheng, Mincui, Mai, Huirong, Yang, Lihua, He, Yingyi, He, Xiangling, Xu, Honggui, Wen, Hong, Le, Shaohua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2024; BioMed Central; BMC
• Subjects: Acute myeloid leukemia; Analysis; Antibodies; Bone marrow; Cancer; Cell Movement; Chemotherapy; Child; Children; Councils; Flow Cytometry; Health aspects; Hematology; Hematopoietic stem cells; Humans; Leukemia; Leukemia, Myeloid; Medical prognosis; Medical research; Methods; Minimal residual disease; Morphology; Multiparametric flow cytometry; Multivariate analysis; Mutation; Neoplasm, Residual; Oncology, Experimental; Pathologic Complete Response; Patients; Pediatric acute myeloid leukemia; Pediatrics; Prognosis; Prognostic value; Remission; Remission (Medicine); Stem cell transplantation; Transplantation; China; United States > US; Prognostic value; Minimal residual disease; Multiparametric flow cytometry; Pediatric acute myeloid leukemia

Prompt response to induction chemotherapy is a prognostic factor in pediatric acute myeloid leukemia. In this study, we aimed to evaluate the prognostic significance of multiparametric flow cytometry-minimal residual disease (MFC-MRD), assessed at the end of the first and second induction courses. M...