Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease - Parbo, Peter; Madsen, Lasse Stensvig; Ismail, Rola; Zetterberg, Henrik; Blennow, Kaj; Eskildsen, Simon F.; Vorup-Jensen, Thomas; Brooks, David J. (Alzheimer's research & therapy, 2020)
Keywords: Advertising executives; Aged; Alzheimer; Alzheimer Disease - immunology; Alzheimer Disease - pathology; Alzheimer's disease; Biomarkers; Biomarkers - blood; Brain; Brain damage; Carbon Radioisotopes; cerebrospinal-fluid; Cluster analysis; Cognitive Dysfunction - immunology; Cognitive Dysfunction - pathology; Cytoplasmic filaments; Dementia; Development and progression; Diagnostic imaging; Diseases; Drug therapy; Female; Health aspects; Humans; Immune response; Immunotherapy; Inflammation; Inflammation - immunology; Inflammation - pathology; Isoquinolines; Magnetic Resonance Imaging; Male; MCI; Medical imaging; Microglia; Microglia - immunology; Middle Aged; mild cognitive impairment; Neurofilament light; Neurofilament Proteins - blood; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; PET; Physiological aspects; PK11195; Plasma; Positron emission tomography; Positron-Emission Tomography - methods; Prodromal Symptoms; Proteins; Radiopharmaceuticals; Registration; Synapses; Tomography; Europe; MCI; PK11195; Neurofilament light; Inflammation; Alzheimer; PET; Microglia