Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

• Published in: Journal of translational medicine Vol. 19; no. 1; pp. 96 - 14
• Main Authors: Li, Jiucui, Lu, Kongmiao, Sun, Fenglan, Tan, Shanjuan, Zhang, Xiao, Sheng, Wei, Hao, Wanming, Liu, Min, Lv, Weihong, Han, Wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.03.2021; BioMed Central; BMC
• Subjects: Acute lung injury; Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute respiratory distress syndrome; Animals; Apoptosis; Biomarkers; Care and treatment; Cell culture; Cell Line; Chemical properties; Cytokines; Development and progression; Diynes - pharmacology; Edema; Epithelial cells; Fatty alcohols; Fatty Alcohols - pharmacology; Ferroptosis; Ginseng; Health aspects; Heme Oxygenase-1; Humans; Immunogenicity; Inflammation; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; LPS; Lung - metabolism; Lungs; Mice; Mice, Inbred C57BL; Molecular modelling; Morbidity; Mortality; Neutrophils; NF-E2-Related Factor 2 - metabolism; Panaxydol; Physiological aspects; Phytochemicals; Proteins; Respiratory distress syndrome; China; United States > US; Acute lung injury; Ferroptosis; Inflammation; LPS; Panaxydol

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In recent years, many bioactive ingredients extracted from herbs have been reported to effectively...