Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel

• Published in: Journal of experimental & clinical cancer research Vol. 36; no. 1; p. 178
• Main Authors: Yang, Zhan, Chen, Jin-Suo, Wen, Jin-Kun, Gao, Hai-Tao, Zheng, Bin, Qu, Chang-Bao, Liu, Kai-Long, Zhang, Man-Li, Gu, Jun-Fei, Li, Jing-Dong, Zhang, Yan-Ping, Li, Wei, Wang, Xiao-Lu, Zhang, Yong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.12.2017; BioMed Central; BMC
• Subjects: Apoptosis; Bach2; Cancer; Chemoresistance; Chemotherapy; Docetaxel; Genes; HO-1; miR-193a-5p; Prostate cancer; RNA; Bach2; HO-1; miR-193a-5p; Prostate cancer; Chemoresistance; Docetaxel

Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of prostate cancer (PC) cells to docetaxel-induced apoptosis. Hence, there is an urgent need to identify mechanisms of docetaxel chemoresistance and to develop new combination therapies....