MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling - Mao, Meng; Xu, Yi; Zhang, Xin-Yu; Yang, Lin; An, Xiao-bin; Qu, Yang; Chai, Ya-ni; Wang, Yan-Ru; Li, Ting-ting; Ai, Jing (Journal of neuroinflammation, 2020)
Keywords: Animal models; Animals; Binding sites; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain research; Carotid arteries; Carotid artery; Cell activation; Cell culture; Cell Line; Cell Polarity - physiology; Cellular signal transduction; Cerebral blood flow; Cerebral circulation; Chemokine CX3CL1 - metabolism; Chemokines; Chronic brain hypoperfusion; CX3C Chemokine Receptor 1 - metabolism; CX3CR1 protein; Disease; Disease Models, Animal; Down-Regulation; Experiments; Flow cytometry; Gene Expression Regulation; Genetic aspects; Genotype & phenotype; Health aspects; Hippocampus; Hippocampus - metabolism; Humidity; Hypoxia; Immunofluorescence; Inflammation; Injection; Ischemia; Laboratory animals; Macrophages; Macrophages - metabolism; Male; Microglia; Microglia - metabolism; Microglial/macrophage polarization; MicroRNA; MicroRNA-195; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular modelling; Neonates; Neuroinflammation; Neuronal-microglial cross-talk; Neurons; Neurons - metabolism; Oligonucleotides; Perfusion (Physiology); Phenotypes; Polarization; Rats; Rats, Sprague-Dawley; Signal Transduction - physiology; Surgery; Sutures; Transfection; Traumatic brain injury; Veins & arteries; China; United States--US; Switzerland; MicroRNA-195; Neuroinflammation; Neuronal-microglial cross-talk; Chronic brain hypoperfusion; Microglial/macrophage polarization