CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection
The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resul...
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Published in | PLoS pathogens Vol. 7; no. 11; p. e1002374 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Public Library of Science
01.11.2011
Public Library of Science (PLoS) |
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Abstract | The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resulting from these actions. Here we demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus. These innate immune effector cells are comprised primarily of CD11b⁺Ly6C⁺Ly6G⁻ monocytes that accumulate initially at the site of infection, and are then supplemented and eventually replaced by CD11b⁺Ly6C⁺Ly6G⁺ cells. The phenotype of the CD11b⁺Ly6C⁺Ly6G⁺ cells resembles neutrophils, but the infiltration of neutrophils typically occurs prior to, rather than following, accumulation of monocytes. Indeed, it appears that the CD11b⁺Ly6C⁺Ly6G⁺ cells that infiltrated the site of VACV infection in the ear are phenotypically distinct from the classical description of both neutrophils and monocyte/macrophages. We found that CD11b⁺Ly6C⁺Ly6G⁺ cells produce Type I interferons and large quantities of reactive oxygen species. We also observed that depletion of Ly6G⁺ cells results in a dramatic increase in tissue damage at the site of infection. Tissue damage is also increased in the absence of reactive oxygen species, although reactive oxygen species are typically thought to be damaging to tissue rather than protective. These data indicate the existence of a specialized population of CD11b⁺Ly6C⁺Ly6G⁺ cells that infiltrates a site of virus infection late and protects the infected tissue from immune-mediated damage via production of reactive oxygen species. Regulation of the action of this population of cells may provide an intervention to prevent innate immune-mediated tissue destruction. |
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AbstractList |
The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resulting from these actions. Here we demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus. These innate immune effector cells are comprised primarily of CD11b+Ly6C+Ly6G- monocytes that accumulate initially at the site of infection, and are then supplemented and eventually replaced by CD11b+Ly6C+Ly6G+ cells. The phenotype of the CD11b+Ly6C+Ly6G+ cells resembles neutrophils, but the infiltration of neutrophils typically occurs prior to, rather than following, accumulation of monocytes. Indeed, it appears that the CD11b+Ly6C+Ly6G+ cells that infiltrated the site of VACV infection in the ear are phenotypically distinct from the classical description of both neutrophils and monocyte/macrophages. We found that CD11b+Ly6C+Ly6G+ cells produce Type I interferons and large quantities of reactive oxygen species. We also observed that depletion of Ly6G+ cells results in a dramatic increase in tissue damage at the site of infection. Tissue damage is also increased in the absence of reactive oxygen species, although reactive oxygen species are typically thought to be damaging to tissue rather than protective. These data indicate the existence of a specialized population of CD11b+Ly6C+Ly6G+ cells that infiltrates a site of virus infection late and protects the infected tissue from immune-mediated damage via production of reactive oxygen species. Regulation of the action of this population of cells may provide an intervention to prevent innate immune-mediated tissue destruction. The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resulting from these actions. Here we demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus. These innate immune effector cells are comprised primarily of CD11b+Ly6C+Ly6G- monocytes that accumulate initially at the site of infection, and are then supplemented and eventually replaced by CD11b+Ly6C+Ly6G+ cells. The phenotype of the CD11b+Ly6C+Ly6G+ cells resembles neutrophils, but the infiltration of neutrophils typically occurs prior to, rather than following, accumulation of monocytes. Indeed, it appears that the CD11b+Ly6C+Ly6G+ cells that infiltrated the site of VACV infection in the ear are phenotypically distinct from the classical description of both neutrophils and monocyte/macrophages. We found that CD11b+Ly6C+Ly6G+ cells produce Type I interferons and large quantities of reactive oxygen species. We also observed that depletion of Ly6G+ cells results in a dramatic increase in tissue damage at the site of infection. Tissue damage is also increased in the absence of reactive oxygen species, although reactive oxygen species are typically thought to be damaging to tissue rather than protective. These data indicate the existence of a specialized population of CD11b+Ly6C+Ly6G+ cells that infiltrates a site of virus infection late and protects the infected tissue from immune-mediated damage via production of reactive oxygen species. Regulation of the action of this population of cells may provide an intervention to prevent innate immune-mediated tissue destruction. The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resulting from these actions. Here we demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus. These innate immune effector cells are comprised primarily of CD11b + Ly6C + Ly6G - monocytes that accumulate initially at the site of infection, and are then supplemented and eventually replaced by CD11b + Ly6C + Ly6G + cells. The phenotype of the CD11b + Ly6C + Ly6G + cells resembles neutrophils, but the infiltration of neutrophils typically occurs prior to, rather than following, accumulation of monocytes. Indeed, it appears that the CD11b + Ly6C + Ly6G + cells that infiltrated the site of VACV infection in the ear are phenotypically distinct from the classical description of both neutrophils and monocyte/macrophages. We found that CD11b + Ly6C + Ly6G + cells produce Type I interferons and large quantities of reactive oxygen species. We also observed that depletion of Ly6G + cells results in a dramatic increase in tissue damage at the site of infection. Tissue damage is also increased in the absence of reactive oxygen species, although reactive oxygen species are typically thought to be damaging to tissue rather than protective. These data indicate the existence of a specialized population of CD11b + Ly6C + Ly6G + cells that infiltrates a site of virus infection late and protects the infected tissue from immune-mediated damage via production of reactive oxygen species. Regulation of the action of this population of cells may provide an intervention to prevent innate immune-mediated tissue destruction. During a natural virus infection, small doses of infectious virus are deposited at a peripheral infection site, and then a “race” ensues, in which the replicating virus attempts to “outpace” the responding immune system of the host. In the early phases of infection, the innate immune system must contain the infection prior to the development of an effective adaptive response. Here we have characterized the cells of the innate immune system that move to a site of peripheral virus infection, and we find that a subset of these cells display atypical expression of cell surface molecules, timing of infiltration, and function. These cells protect the infected tissue from damage by producing reactive oxygen molecules, which are widely accepted to increase tissue damage. Therefore our findings indicate that during a peripheral virus infection, the typical rules governing the function of the innate immune system are altered to prevent tissue damage. The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limiting undesirable destruction of tissue resulting from these actions. Here we demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus. These innate immune effector cells are comprised primarily of CD11b⁺Ly6C⁺Ly6G⁻ monocytes that accumulate initially at the site of infection, and are then supplemented and eventually replaced by CD11b⁺Ly6C⁺Ly6G⁺ cells. The phenotype of the CD11b⁺Ly6C⁺Ly6G⁺ cells resembles neutrophils, but the infiltration of neutrophils typically occurs prior to, rather than following, accumulation of monocytes. Indeed, it appears that the CD11b⁺Ly6C⁺Ly6G⁺ cells that infiltrated the site of VACV infection in the ear are phenotypically distinct from the classical description of both neutrophils and monocyte/macrophages. We found that CD11b⁺Ly6C⁺Ly6G⁺ cells produce Type I interferons and large quantities of reactive oxygen species. We also observed that depletion of Ly6G⁺ cells results in a dramatic increase in tissue damage at the site of infection. Tissue damage is also increased in the absence of reactive oxygen species, although reactive oxygen species are typically thought to be damaging to tissue rather than protective. These data indicate the existence of a specialized population of CD11b⁺Ly6C⁺Ly6G⁺ cells that infiltrates a site of virus infection late and protects the infected tissue from immune-mediated damage via production of reactive oxygen species. Regulation of the action of this population of cells may provide an intervention to prevent innate immune-mediated tissue destruction. |
Author | Epler, Melanie R Davies, Michael L Ingersoll, Molly A Heipertz, Erica L Norbury, Christopher C Sei, Janet J Fischer, Matthew A Rooijen, Nico Van Reider, Irene E Randolph, Gwendalyn J |
AuthorAffiliation | Ludwig-Maximilians-Universität München, Germany 2 Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York, United States of America 3 Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands 1 Department of Microbiology and Immunology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America |
AuthorAffiliation_xml | – name: 1 Department of Microbiology and Immunology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America – name: 2 Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York, United States of America – name: Ludwig-Maximilians-Universität München, Germany – name: 3 Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands |
Author_xml | – sequence: 1 givenname: Matthew A surname: Fischer fullname: Fischer, Matthew A organization: Department of Microbiology and Immunology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America – sequence: 2 givenname: Michael L surname: Davies fullname: Davies, Michael L – sequence: 3 givenname: Irene E surname: Reider fullname: Reider, Irene E – sequence: 4 givenname: Erica L surname: Heipertz fullname: Heipertz, Erica L – sequence: 5 givenname: Melanie R surname: Epler fullname: Epler, Melanie R – sequence: 6 givenname: Janet J surname: Sei fullname: Sei, Janet J – sequence: 7 givenname: Molly A surname: Ingersoll fullname: Ingersoll, Molly A – sequence: 8 givenname: Nico Van surname: Rooijen fullname: Rooijen, Nico Van – sequence: 9 givenname: Gwendalyn J surname: Randolph fullname: Randolph, Gwendalyn J – sequence: 10 givenname: Christopher C surname: Norbury fullname: Norbury, Christopher C |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22102816$$D View this record in MEDLINE/PubMed https://hal.science/pasteur-01662514$$DView record in HAL |
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Cites_doi | 10.1006/viro.2000.0603 10.1016/j.bbagen.2008.01.006 10.1002/eji.1830181125 10.1016/j.virol.2010.08.001 10.1084/jem.186.9.1591 10.1161/01.RES.0000247067.34173.1b 10.1038/ni.1792 10.1002/eji.200635977 10.1016/j.virol.2007.01.033 10.4049/jimmunol.181.8.5791 10.4049/jimmunol.0900092 10.1084/jem.181.6.2171 10.1073/pnas.91.8.3458 10.1111/j.1524-475X.2008.00436.x 10.1378/chest.116.suppl_1.61S-a 10.1016/j.freeradbiomed.2008.12.003 10.1189/jlb.1107768 10.1038/nri1785 10.1189/jlb.0903442 10.4049/jimmunol.171.6.3034 10.1038/nature09118 10.1038/nri1728 10.1016/j.chom.2010.07.008 10.1016/0022-1759(94)90012-4 10.1038/nri2779 10.1073/pnas.94.20.10925 10.4049/jimmunol.172.2.989 10.1099/vir.0.81556-0 10.1111/j.1600-065X.1995.tb00090.x 10.4049/jimmunol.151.5.2399 10.1586/14760584.7.9.1329 10.1189/jlb.0407247 10.1016/S1074-7613(03)00174-2 10.1007/s00428-003-0918-8 10.1016/j.immuni.2008.05.019 10.1128/JVI.74.7.3404-3409.2000 10.1016/S0092-8674(02)00754-7 10.1086/374780 10.1152/ajpgi.2000.278.2.G259 10.1128/JVI.69.2.910-915.1995 10.1038/ni762 10.4049/jimmunol.172.10.6265 10.1007/BF03401653 10.1038/nri2784 10.1016/j.immuni.2010.07.018 10.1016/j.immuni.2008.11.013 10.1007/s00011-006-0071-3 10.1016/0092-8674(95)90085-3 10.1099/vir.0.021915-0 10.1084/jem.20052119 10.1016/j.immuni.2007.01.017 10.1586/14760584.7.8.1201 10.1084/jem.166.6.1685 10.1073/pnas.161272598 10.1084/jem.20022201 10.4049/jimmunol.165.2.779 10.1084/jem.20080421 10.1099/0022-1317-83-8-1977 10.1099/0022-1317-80-10-2751 10.1038/ng0295-202 10.1099/vir.0.19285-0 10.1038/nature06287 10.1161/hh1401.093314 |
ContentType | Journal Article |
Copyright | 2011 Fischer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Fischer MA, Davies ML, Reider IE, Heipertz EL, Epler MR, et al. (2011) CD11b+, Ly6G+ Cells Produce Type I Interferon and Exhibit Tissue Protective Properties Following Peripheral Virus Infection. PLoS Pathog 7(11): e1002374. doi:10.1371/journal.ppat.1002374 Attribution Fischer et al. 2011 |
Copyright_xml | – notice: 2011 Fischer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Fischer MA, Davies ML, Reider IE, Heipertz EL, Epler MR, et al. (2011) CD11b+, Ly6G+ Cells Produce Type I Interferon and Exhibit Tissue Protective Properties Following Peripheral Virus Infection. PLoS Pathog 7(11): e1002374. doi:10.1371/journal.ppat.1002374 – notice: Attribution – notice: Fischer et al. 2011 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: MAF MLD IER MAI GJR CCN. Performed the experiments: MAF MLD IER CCN. Analyzed the data: MAF MLD MAI CCN. Contributed reagents/materials/analysis tools: MRE ELH JJS NVR CCN. Wrote the paper: MAF CCN. |
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References | 10666050 - Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G259-65 10424595 - Chest. 1999 Jul;116(1 Suppl):61S-63S 19200757 - Immunity. 2009 Feb 20;30(2):277-88 11828323 - Nat Immunol. 2002 Mar;3(3):265-71 9348317 - J Exp Med. 1997 Nov 3;186(9):1591-6 19801985 - Nat Immunol. 2009 Nov;10(11):1200-7 19380816 - J Immunol. 2009 May 1;182(9):5693-701 11463724 - Circ Res. 2001 Jul 20;89(2):168-73 7719350 - Nat Genet. 1995 Feb;9(2):202-9 11447290 - Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8798-803 18779347 - J Exp Med. 2008 Sep 29;205(10):2319-37 18980537 - Expert Rev Vaccines. 2008 Nov;7(9):1329-39 2445894 - J Exp Med. 1987 Dec 1;166(6):1685-701 8360469 - J Immunol. 1993 Sep 1;151(5):2399-408 12867627 - J Gen Virol. 2003 Aug;84(Pt 8):1973-83 20817252 - Virology. 2010 Nov 10;407(1):143-51 12960329 - J Immunol. 2003 Sep 15;171(6):3034-46 14707072 - J Immunol. 2004 Jan 15;172(2):989-99 8972484 - Mol Med. 1996 Nov;2(6):692-701 9380736 - Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10925-30 18691912 - Immunity. 2008 Aug 15;29(2):306-17 20467425 - Nat Rev Immunol. 2010 Jun;10(6):453-60 17008602 - Circ Res. 2006 Oct 27;99(9):943-50 12756265 - J Exp Med. 2003 May 19;197(10):1269-78 16603516 - J Gen Virol. 2006 May;87(Pt 5):1157-61 18844594 - Expert Rev Vaccines. 2008 Oct;7(8):1201-14 20498669 - Nat Rev Immunol. 2010 Jun;10(6):427-39 7539042 - J Exp Med. 1995 Jun 1;181(6):2171-9 8159769 - Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3458-62 17934446 - Nature. 2007 Nov 1;450(7166):110-4 20538903 - J Gen Virol. 2010 Sep;91(Pt 9):2158-66 17412618 - Immunity. 2007 Apr;26(4):519-31 10573171 - J Gen Virol. 1999 Oct;80 ( Pt 10):2751-5 20727790 - Immunity. 2010 Aug 27;33(2):266-78 17331554 - Virology. 2007 Jun 20;363(1):48-58 16703568 - Eur J Immunol. 2006 Jun;36(6):1364-73 8083541 - J Immunol Methods. 1994 Sep 14;174(1-2):83-93 15128815 - J Immunol. 2004 May 15;172(10):6265-71 12721941 - J Infect Dis. 2003 May 15;187(10):1609-15 14726498 - J Leukoc Biol. 2004 Apr;75(4):612-23 17884993 - J Leukoc Biol. 2008 Jan;83(1):64-70 14586652 - Virchows Arch. 2003 Dec;443(6):703-17 18249195 - Biochim Biophys Acta. 2008 Nov;1780(11):1348-61 19152646 - Wound Repair Regen. 2009 Jan-Feb;17(1):1-18 20709294 - Cell Host Microbe. 2010 Aug 19;8(2):174-85 12871640 - Immunity. 2003 Jul;19(1):71-82 20577213 - Nature. 2010 Jun 24;465(7301):1079-83 18611985 - J Leukoc Biol. 2008 Sep;84(3):644-50 18832739 - J Immunol. 2008 Oct 15;181(8):5791-802 16498448 - Nat Rev Immunol. 2006 Mar;6(3):173-82 16830107 - Inflamm Res. 2006 May;55(5):200-6 7538909 - Cell. 1995 May 19;81(4):641-50 12062105 - Cell. 2002 May 31;109(5):625-37 7529336 - J Virol. 1995 Feb;69(2):910-5 10878351 - J Immunol. 2000 Jul 15;165(2):779-85 10708458 - J Virol. 2000 Apr;74(7):3404-9 11080491 - Virology. 2000 Nov 25;277(2):439-49 12124461 - J Gen Virol. 2002 Aug;83(Pt 8):1977-86 16492803 - J Exp Med. 2006 Mar 20;203(3):583-97 19124074 - Free Radic Biol Med. 2009 Mar 15;46(6):791-8 16239901 - Nat Rev Immunol. 2005 Dec;5(12):905-16 2849552 - Eur J Immunol. 1988 Nov;18(11):1819-26 8825279 - Immunol Rev. 1995 Dec;148:5-18 B Heissig (ref49) 2002; 109 JA Mikszta (ref6) 2008; 7 R Xu (ref11) 2004; 172 J Komatsu (ref40) 2006; 55 O Soehnlein (ref3) 2010; 10 CA Schaer (ref44) 2006; 99 B Leon (ref12) 2007; 26 N van Rooijen (ref20) 1994; 174 JD Pollock (ref33) 1995; 9 M Wojtasiak (ref16) 2010; 91 M Iannacone (ref51) 2010; 465 CC Norbury (ref52) 2002; 3 DR Getts (ref14) 2008; 205 DC Tscharke (ref7) 2002; 83 S Kusmartsev (ref59) 2004; 172 F Facchetti (ref34) 2003; 443 JB McLachlan (ref35) 2009; 30 N Jacobs (ref9) 2006; 87 R Rivera (ref17) 2007; 363 H Rosen (ref63) 1987; 166 M Wojtasiak (ref15) 2010; 407 ML Jaffe (ref55) 1996; 2 SH Burnett (ref21) 2004; 75 F Geissmann (ref60) 2010; 10 F Geissmann (ref26) 2003; 19 SA Kusmartsev (ref56) 2000; 165 KD Poss (ref45) 1997; 94 JI Youn (ref57) 2008; 181 JD MacMicking (ref61) 1995; 81 T Minamino (ref46) 2001; 98 WE O'Gorman (ref18) 2010; 8 T Junt (ref50) 2007; 450 CK Sen (ref38) 2008; 1780 TG Blanchard (ref39) 2003; 187 PC Reading (ref10) 2003; 84 SF Yet (ref48) 2001; 89 JF Nicolas (ref4) 2008; 7 C Nathan (ref2) 2006; 6 S Hatakeyama (ref23) 1994; 91 CK Sen (ref37) 2009; 17 RC Chou (ref1) 2010; 33 R Barbalat (ref19) 2009; 10 WJ Zhang (ref42) 2009; 46 LE Otterbein (ref47) 1999; 116 GJ Wright (ref43) 2003; 171 S Mitragotri (ref5) 2005; 5 J Ruby (ref28) 1997; 186 R Deonarain (ref31) 2000; 74 MF van den Broek (ref32) 1995; 148 G Varga (ref54) 2008; 84 CA Corzo (ref58) 2009; 182 N Harris (ref29) 1995; 69 MA Jutila (ref22) 1988; 18 G Karupiah (ref30) 1995; 181 TJ Fleming (ref24) 1993; 151 PC Reading (ref53) 2003; 197 F Tacke (ref27) 2006; 203 F Galeazzi (ref62) 2000; 278 RJ Snelgrove (ref41) 2006; 36 DC Tscharke (ref8) 1999; 80 CR Damaso (ref36) 2000; 277 IR Dunay (ref13) 2008; 29 JM Daley (ref25) 2008; 83 |
References_xml | – volume: 277 start-page: 439 year: 2000 ident: ref36 article-title: An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine. publication-title: Virology doi: 10.1006/viro.2000.0603 contributor: fullname: CR Damaso – volume: 1780 start-page: 1348 year: 2008 ident: ref38 article-title: Redox signals in wound healing. publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagen.2008.01.006 contributor: fullname: CK Sen – volume: 18 start-page: 1819 year: 1988 ident: ref22 article-title: Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. publication-title: Eur J Immunol doi: 10.1002/eji.1830181125 contributor: fullname: MA Jutila – volume: 407 start-page: 143 year: 2010 ident: ref15 article-title: Gr-1(+) cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1. publication-title: Virology doi: 10.1016/j.virol.2010.08.001 contributor: fullname: M Wojtasiak – volume: 186 start-page: 1591 year: 1997 ident: ref28 article-title: Antiviral activity of tumor necrosis factor (TNF) is mediated via p55 and p75 TNF receptors. publication-title: J Exp Med doi: 10.1084/jem.186.9.1591 contributor: fullname: J Ruby – volume: 99 start-page: 943 year: 2006 ident: ref44 article-title: Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. publication-title: Circ Res doi: 10.1161/01.RES.0000247067.34173.1b contributor: fullname: CA Schaer – volume: 10 start-page: 1200 year: 2009 ident: ref19 article-title: Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. publication-title: Nat Immunol doi: 10.1038/ni.1792 contributor: fullname: R Barbalat – volume: 36 start-page: 1364 year: 2006 ident: ref41 article-title: An absence of reactive oxygen species improves the resolution of lung influenza infection. publication-title: Eur J Immunol doi: 10.1002/eji.200635977 contributor: fullname: RJ Snelgrove – volume: 363 start-page: 48 year: 2007 ident: ref17 article-title: Murine alveolar macrophages limit replication of vaccinia virus. publication-title: Virology doi: 10.1016/j.virol.2007.01.033 contributor: fullname: R Rivera – volume: 181 start-page: 5791 year: 2008 ident: ref57 article-title: Subsets of myeloid-derived suppressor cells in tumor-bearing mice. publication-title: J Immunol doi: 10.4049/jimmunol.181.8.5791 contributor: fullname: JI Youn – volume: 182 start-page: 5693 year: 2009 ident: ref58 article-title: Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. publication-title: J Immunol doi: 10.4049/jimmunol.0900092 contributor: fullname: CA Corzo – volume: 181 start-page: 2171 year: 1995 ident: ref30 article-title: Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites. publication-title: J Exp Med doi: 10.1084/jem.181.6.2171 contributor: fullname: G Karupiah – volume: 91 start-page: 3458 year: 1994 ident: ref23 article-title: The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.91.8.3458 contributor: fullname: S Hatakeyama – volume: 17 start-page: 1 year: 2009 ident: ref37 article-title: Wound healing essentials: let there be oxygen. publication-title: Wound Repair Regen doi: 10.1111/j.1524-475X.2008.00436.x contributor: fullname: CK Sen – volume: 116 start-page: 61S year: 1999 ident: ref47 article-title: Protective effects of heme oxygenase-1 in acute lung injury. publication-title: Chest doi: 10.1378/chest.116.suppl_1.61S-a contributor: fullname: LE Otterbein – volume: 46 start-page: 791 year: 2009 ident: ref42 article-title: Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo. publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2008.12.003 contributor: fullname: WJ Zhang – volume: 84 start-page: 644 year: 2008 ident: ref54 article-title: Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells. publication-title: J Leukoc Biol doi: 10.1189/jlb.1107768 contributor: fullname: G Varga – volume: 6 start-page: 173 year: 2006 ident: ref2 article-title: Neutrophils and immunity: challenges and opportunities. publication-title: Nat Rev Immunol doi: 10.1038/nri1785 contributor: fullname: C Nathan – volume: 75 start-page: 612 year: 2004 ident: ref21 article-title: Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. publication-title: J Leukoc Biol doi: 10.1189/jlb.0903442 contributor: fullname: SH Burnett – volume: 171 start-page: 3034 year: 2003 ident: ref43 article-title: Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. publication-title: J Immunol doi: 10.4049/jimmunol.171.6.3034 contributor: fullname: GJ Wright – volume: 465 start-page: 1079 year: 2010 ident: ref51 article-title: Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. publication-title: Nature doi: 10.1038/nature09118 contributor: fullname: M Iannacone – volume: 5 start-page: 905 year: 2005 ident: ref5 article-title: Immunization without needles. publication-title: Nat Rev Immunol doi: 10.1038/nri1728 contributor: fullname: S Mitragotri – volume: 8 start-page: 174 year: 2010 ident: ref18 article-title: Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses. publication-title: Cell Host Microbe doi: 10.1016/j.chom.2010.07.008 contributor: fullname: WE O'Gorman – volume: 174 start-page: 83 year: 1994 ident: ref20 article-title: Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. publication-title: J Immunol Methods doi: 10.1016/0022-1759(94)90012-4 contributor: fullname: N van Rooijen – volume: 10 start-page: 427 year: 2010 ident: ref3 article-title: Phagocyte partnership during the onset and resolution of inflammation. publication-title: Nat Rev Immunol doi: 10.1038/nri2779 contributor: fullname: O Soehnlein – volume: 94 start-page: 10925 year: 1997 ident: ref45 article-title: Reduced stress defense in heme oxygenase 1-deficient cells. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.20.10925 contributor: fullname: KD Poss – volume: 172 start-page: 989 year: 2004 ident: ref59 article-title: Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. publication-title: J Immunol doi: 10.4049/jimmunol.172.2.989 contributor: fullname: S Kusmartsev – volume: 87 start-page: 1157 year: 2006 ident: ref9 article-title: Intradermal immune response after infection with Vaccinia virus. publication-title: J Gen Virol doi: 10.1099/vir.0.81556-0 contributor: fullname: N Jacobs – volume: 148 start-page: 5 year: 1995 ident: ref32 article-title: Immune defence in mice lacking type I and/or type II interferon receptors. publication-title: Immunol Rev doi: 10.1111/j.1600-065X.1995.tb00090.x contributor: fullname: MF van den Broek – volume: 151 start-page: 2399 year: 1993 ident: ref24 article-title: Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. publication-title: J Immunol doi: 10.4049/jimmunol.151.5.2399 contributor: fullname: TJ Fleming – volume: 7 start-page: 1329 year: 2008 ident: ref6 article-title: Cutaneous delivery of prophylactic and therapeutic vaccines: historical perspective and future outlook. publication-title: Expert Rev Vaccines doi: 10.1586/14760584.7.9.1329 contributor: fullname: JA Mikszta – volume: 83 start-page: 64 year: 2008 ident: ref25 article-title: Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. publication-title: J Leukoc Biol doi: 10.1189/jlb.0407247 contributor: fullname: JM Daley – volume: 19 start-page: 71 year: 2003 ident: ref26 article-title: Blood monocytes consist of two principal subsets with distinct migratory properties. publication-title: Immunity doi: 10.1016/S1074-7613(03)00174-2 contributor: fullname: F Geissmann – volume: 443 start-page: 703 year: 2003 ident: ref34 article-title: The plasmacytoid monocyte/interferon producing cells. publication-title: Virchows Arch doi: 10.1007/s00428-003-0918-8 contributor: fullname: F Facchetti – volume: 29 start-page: 306 year: 2008 ident: ref13 article-title: Gr1(+) Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii. publication-title: Immunity doi: 10.1016/j.immuni.2008.05.019 contributor: fullname: IR Dunay – volume: 74 start-page: 3404 year: 2000 ident: ref31 article-title: Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. publication-title: J Virol doi: 10.1128/JVI.74.7.3404-3409.2000 contributor: fullname: R Deonarain – volume: 109 start-page: 625 year: 2002 ident: ref49 article-title: Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. publication-title: Cell doi: 10.1016/S0092-8674(02)00754-7 contributor: fullname: B Heissig – volume: 187 start-page: 1609 year: 2003 ident: ref39 article-title: Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. publication-title: J Infect Dis doi: 10.1086/374780 contributor: fullname: TG Blanchard – volume: 278 start-page: G259 year: 2000 ident: ref62 article-title: Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.2000.278.2.G259 contributor: fullname: F Galeazzi – volume: 69 start-page: 910 year: 1995 ident: ref29 article-title: Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication. publication-title: J Virol doi: 10.1128/JVI.69.2.910-915.1995 contributor: fullname: N Harris – volume: 3 start-page: 265 year: 2002 ident: ref52 article-title: Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. publication-title: Nat Immunol doi: 10.1038/ni762 contributor: fullname: CC Norbury – volume: 172 start-page: 6265 year: 2004 ident: ref11 article-title: Cellular and humoral immunity against vaccinia virus infection of mice. publication-title: J Immunol doi: 10.4049/jimmunol.172.10.6265 contributor: fullname: R Xu – volume: 2 start-page: 692 year: 1996 ident: ref55 article-title: Mechanisms of tumor-induced immunosuppression: evidence for contact-dependent T cell suppression by monocytes. publication-title: Mol Med doi: 10.1007/BF03401653 contributor: fullname: ML Jaffe – volume: 10 start-page: 453 year: 2010 ident: ref60 article-title: Unravelling mononuclear phagocyte heterogeneity. publication-title: Nat Rev Immunol doi: 10.1038/nri2784 contributor: fullname: F Geissmann – volume: 33 start-page: 266 year: 2010 ident: ref1 article-title: Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. publication-title: Immunity doi: 10.1016/j.immuni.2010.07.018 contributor: fullname: RC Chou – volume: 30 start-page: 277 year: 2009 ident: ref35 article-title: Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. publication-title: Immunity doi: 10.1016/j.immuni.2008.11.013 contributor: fullname: JB McLachlan – volume: 55 start-page: 200 year: 2006 ident: ref40 article-title: Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase. publication-title: Inflamm Res doi: 10.1007/s00011-006-0071-3 contributor: fullname: J Komatsu – volume: 81 start-page: 641 year: 1995 ident: ref61 article-title: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. publication-title: Cell doi: 10.1016/0092-8674(95)90085-3 contributor: fullname: JD MacMicking – volume: 91 start-page: 2158 year: 2010 ident: ref16 article-title: Depletion of Gr-1+, but not Ly6G+, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection. publication-title: J Gen Virol doi: 10.1099/vir.0.021915-0 contributor: fullname: M Wojtasiak – volume: 203 start-page: 583 year: 2006 ident: ref27 article-title: Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. publication-title: J Exp Med doi: 10.1084/jem.20052119 contributor: fullname: F Tacke – volume: 26 start-page: 519 year: 2007 ident: ref12 article-title: Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. publication-title: Immunity doi: 10.1016/j.immuni.2007.01.017 contributor: fullname: B Leon – volume: 7 start-page: 1201 year: 2008 ident: ref4 article-title: Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice. publication-title: Expert Rev Vaccines doi: 10.1586/14760584.7.8.1201 contributor: fullname: JF Nicolas – volume: 166 start-page: 1685 year: 1987 ident: ref63 article-title: Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. publication-title: J Exp Med doi: 10.1084/jem.166.6.1685 contributor: fullname: H Rosen – volume: 98 start-page: 8798 year: 2001 ident: ref46 article-title: Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.161272598 contributor: fullname: T Minamino – volume: 197 start-page: 1269 year: 2003 ident: ref53 article-title: Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection. publication-title: J Exp Med doi: 10.1084/jem.20022201 contributor: fullname: PC Reading – volume: 165 start-page: 779 year: 2000 ident: ref56 article-title: Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. publication-title: J Immunol doi: 10.4049/jimmunol.165.2.779 contributor: fullname: SA Kusmartsev – volume: 205 start-page: 2319 year: 2008 ident: ref14 article-title: Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. publication-title: J Exp Med doi: 10.1084/jem.20080421 contributor: fullname: DR Getts – volume: 83 start-page: 1977 year: 2002 ident: ref7 article-title: Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes. publication-title: J Gen Virol doi: 10.1099/0022-1317-83-8-1977 contributor: fullname: DC Tscharke – volume: 80 start-page: 2751 year: 1999 ident: ref8 article-title: A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnae. publication-title: J Gen Virol doi: 10.1099/0022-1317-80-10-2751 contributor: fullname: DC Tscharke – volume: 9 start-page: 202 year: 1995 ident: ref33 article-title: Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. publication-title: Nat Genet doi: 10.1038/ng0295-202 contributor: fullname: JD Pollock – volume: 84 start-page: 1973 year: 2003 ident: ref10 article-title: A kinetic analysis of immune mediators in the lungs of mice infected with vaccinia virus and comparison with intradermal infection. publication-title: J Gen Virol doi: 10.1099/vir.0.19285-0 contributor: fullname: PC Reading – volume: 450 start-page: 110 year: 2007 ident: ref50 article-title: Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. publication-title: Nature doi: 10.1038/nature06287 contributor: fullname: T Junt – volume: 89 start-page: 168 year: 2001 ident: ref48 article-title: Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. publication-title: Circ Res doi: 10.1161/hh1401.093314 contributor: fullname: SF Yet |
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Snippet | The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response.... The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response.... |
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SubjectTerms | Animals Antigens, Ly Antigens, Ly - analysis Bacterial infections Biology CD11b Antigen CD11b Antigen - analysis Colleges & universities Cytokines Flow cytometry Immune system Immunity, Innate Immunology Infections Interferon Type I Interferon Type I - biosynthesis Interferon Type I - immunology Life Sciences Macrophages Macrophages - immunology Macrophages - virology Medical research Medicine Mice Mice, Inbred C57BL Mice, Knockout Monocytes Monocytes - immunology Monocytes - virology Neutrophils Neutrophils - immunology Neutrophils - virology Nitric oxide Organized crime Reactive Oxygen Species Reactive Oxygen Species - metabolism Vaccinia Vaccinia - immunology Vaccinia - virology Vaccinia virus Vaccinia virus - immunology Vaccinia virus - pathogenicity Viral infections |
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Title | CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection |
URI | https://www.ncbi.nlm.nih.gov/pubmed/22102816 https://www.proquest.com/docview/1289086979/abstract/ https://search.proquest.com/docview/905681831 https://hal.science/pasteur-01662514 https://pubmed.ncbi.nlm.nih.gov/PMC3213107 https://doaj.org/article/f75a40044a7044648ae1e7a84fec089f http://dx.doi.org/10.1371/journal.ppat.1002374 |
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