The CLDN5 gene at the blood-brain barrier in health and disease

• Published in: Fluids and barriers of the CNS Vol. 20; no. 1; p. 22
• Main Authors: Hashimoto, Yosuke, Greene, Chris, Munnich, Arnold, Campbell, Matthew
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.03.2023; BioMed Central; BMC
• Subjects: Animals; Astrocytes; Astrocytes - metabolism; Biological Transport; Blood vessels; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain - metabolism; Calcification; Children; Claudin-5; Claudin-5 - genetics; Claudin-5 - metabolism; Dementia disorders; Development and progression; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Epilepsy; Estrogens; Genes; Genetic research; Hemiplegia; Homeostasis; Humans; Life Sciences; Localization; Mental disorders; Mice; Microenvironments; Microscopy; Microvasculature; Missense mutation; Mutagenesis; Mutation; Nervous system diseases; Neurological diseases; Neurons and Cognition; Paralysis; Pericytes; Permeability; Physiological aspects; Proteins; Psychiatric diseases; Review; Shear stress; Solutes; Tight junction; Tight junctions; Tight Junctions - metabolism; Vascular permeability; Claudin-5; Tight junction; Psychiatric diseases; Vascular permeability; Blood–brain barrier

The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain microvascular endothelial cells and associated pericytes and end-feet of astrocytes, is...