Patient-derived xenograft (PDX) models, applications and challenges in cancer research

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of...

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Published inJournal of translational medicine Vol. 20; no. 1; pp. 206 - 15
Main Authors Abdolahi, Shahrokh, Ghazvinian, Zeinab, Muhammadnejad, Samad, Saleh, Mahshid, Asadzadeh Aghdaei, Hamid, Baghaei, Kaveh
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 10.05.2022
BioMed Central
BMC
Subjects
Animal models in research
Animals
Antitumor agents
Avatar model of cancer
Cancer
Cancer animal model
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
COVID-19
Disease Models, Animal
Drug development
Drugs
Gene expression
Heterografts
Humanized model
Humans
Immune system
Immunotherapy
Medical research
Neoplasms - pathology
Patient outcomes
Patients
PDX
Precision medicine
Precision Medicine - methods
Preclinical study
Prevention
Review
Success
Transplants & implants
Tumor Microenvironment
Tumors
Validity
Xenograft Model Antitumor Assays
Xenografts
Xenotransplantation
United States
Preclinical study
Humanized model
PDX
Avatar model of cancer
Cancer animal model
Online AccessGet full text

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Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
AbstractList The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations. Keywords: Cancer animal model, PDX, Preclinical study, Humanized model, Avatar model of cancer
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
ArticleNumber 206
Audience Academic
Author Saleh, Mahshid
Muhammadnejad, Samad
Baghaei, Kaveh
Asadzadeh Aghdaei, Hamid
Abdolahi, Shahrokh
Ghazvinian, Zeinab
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  surname: Abdolahi
  fullname: Abdolahi, Shahrokh
– sequence: 2
  givenname: Zeinab
  surname: Ghazvinian
  fullname: Ghazvinian, Zeinab
– sequence: 3
  givenname: Samad
  surname: Muhammadnejad
  fullname: Muhammadnejad, Samad
– sequence: 4
  givenname: Mahshid
  surname: Saleh
  fullname: Saleh, Mahshid
– sequence: 5
  givenname: Hamid
  surname: Asadzadeh Aghdaei
  fullname: Asadzadeh Aghdaei, Hamid
– sequence: 6
  givenname: Kaveh
  orcidid: 0000-0003-2102-9729
  surname: Baghaei
  fullname: Baghaei, Kaveh
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35538576$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/jjco/hyaa089
10.3390/cancers12071915
10.1096/fj.201700740R
10.1016/j.jtho.2019.12.065
10.3390/cells8050505
10.1038/bjc.2013.132
10.1002/gcc.10097
10.1038/s41598-019-48634-y
10.1111/j.1440-1827.2008.02271.x
10.1038/sj.bjc.6605900
10.1007/s10585-020-10033-3
10.1038/nrclinonc.2015.62
10.1186/s13045-019-0829-z
10.1158/2159-8290.CD-16-1154
10.1158/1078-0432.CCR-07-0078
10.1002/cam4.357
10.1371/journal.pone.0134493
10.3389/fimmu.2020.01109/full
10.1007/978-1-4939-3139-2_10
10.1002/path.4459
10.1016/j.it.2018.07.001
10.1038/srep09447
10.1186/bcr2358
10.3389/fimmu.2021.687715
10.1016/j.cell.2015.08.068
10.1006/cimm.1996.0193
10.1016/j.canlet.2019.10.027
10.1182/blood.V88.10.3731.bloodjournal88103731
10.1002/ijc.30472
10.4049/jimmunol.154.1.180
10.1002/pros.20225
10.1158/0008-5472.CAN-14-0274
10.1158/2159-8290.CD-11-0061
10.1002/pros.23701
10.1158/0008-5472.CAN-14-3510
10.1146/annurev-pathol-052016-100332
10.1002/path.2929
10.1016/j.diff.2015.10.012
10.1158/1535-7163.MCT-11-0937
10.1158/2159-8290.CD-18-0044
10.1136/gutjnl-2017-315201
10.1200/JCO.2015.63.2497
10.1080/17460441.2017.1281245
10.1007/s13238-017-0472-9
10.3390/cells8060585
10.1371/journal.pone.0079874
10.1097/MD.0000000000000298
10.1158/0008-5472.CAN-06-0594
10.1007/s12094-010-0540-6
10.1038/s41571-019-0268-3
10.21037/tlcr-20-154
10.1016/j.neo.2018.02.003
10.1242/dmm.028274
10.1016/j.molonc.2013.03.004
10.1158/2159-8290.CD-14-0001
10.1158/1078-0432.CCR-06-0252
10.1038/nature13952
10.1002/pros.10179
10.1016/j.cllc.2016.09.012
10.1101/cshperspect.a005058
10.1111/cei.12180
10.18632/oncotarget.11184
10.1038/nm.2454
10.1016/0092-8674(95)90360-7
10.4049/jimmunol.150.9.3817
10.1038/nature.2016.19364
10.1007/s00005-018-0506-x
10.1158/2159-8290.CD-11-0109
10.1158/0008-5472.CAN-16-0122
10.1016/j.molonc.2013.11.010
10.1016/j.jss.2013.11.010
10.1002/path.4772
10.1158/1078-0432.CCR-08-0138
10.1038/372103a0
10.1016/j.ejcts.2009.03.054
10.4049/jimmunol.174.10.6477
10.1002/pros.23313
10.18632/oncotarget.6919
10.3390/cancers12041025
10.1038/nature11814
10.3389/fonc.2017.00002
10.1186/s12967-018-1516-5
10.1016/j.canlet.2013.10.010
10.1038/nrd2110
10.1016/j.ccell.2014.11.013
10.3390/cancers11101520
10.1002/pros.22939
10.1158/1078-0432.CCR-11-0341
10.1016/j.csbj.2020.01.008
10.1038/ng.3224
10.1007/978-3-319-55825-7
10.1038/nm.3954
10.1158/1078-0432.CCR-12-0372
10.1093/annonc/mdx416
10.1038/srep22172
10.1158/1078-0432.CCR-12-2408
10.1371/journal.pone.0163521
10.3389/fmed.2019.00139
10.1186/s42826-020-00045-1
10.1158/1078-0432.CCR-12-1740
10.1186/1479-5876-11-168
10.1016/j.addr.2015.07.007
10.3390/cells8080889
10.1186/s13046-015-0243-5
10.1038/nature06489
10.1016/j.canlet.2019.01.031
10.1158/1078-0432.CCR-10-2224
10.1016/j.annonc.2019.11.007
10.1158/0008-5472.CAN-15-0727
10.1038/s41598-016-0001-8
10.1007/978-1-4939-9145-7_15
10.1038/nrclinonc.2011.34
10.1038/nrg3967
10.1245/s10434-015-4425-3
10.1007/s10549-012-2226-y
10.1158/0008-5472.CAN-12-4081
10.1158/0008-5472.CAN-10-2880
10.18632/oncotarget.3925
10.1016/j.annonc.2019.11.002
10.4049/jimmunol.180.10.7009
10.1155/2016/1715053
10.4143/crt.2017.307
10.1126/scitranslmed.3003643
10.1158/0008-5472.CAN-14-1590
10.1146/annurev-cancerbio-050216-122002
10.1016/j.bbrc.2005.05.097
10.1007/s10555-016-9653-x
10.1038/nature17676
10.3390/cells8060621
10.1038/nrclinonc.2012.61
10.3390/jpm10030064
10.1007/978-3-319-55825-7_2
10.1054/bjoc.2001.1796
10.1038/nm0910-974
10.1158/2326-6066.IMM2016-B126
10.1002/path.4824
10.1038/nrc.2016.140
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Issue 1
Keywords Preclinical study
Humanized model
PDX
Avatar model of cancer
Cancer animal model
Language English
License 2022. The Author(s).
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References S Okada (3405_CR17) 2019; 8
K Jin (3405_CR22) 2010; 12
HJ Hedrich (3405_CR2) 2012
H Huynh (3405_CR129) 2015; 34
P Nanni (3405_CR46) 2019; 9
H Gao (3405_CR34) 2015; 21
A Sobarzo (3405_CR53) 2020; 15
S-Y Cho (3405_CR111) 2020; 36
JJ Tentler (3405_CR16) 2012; 9
T Schatton (3405_CR43) 2008; 451
T Murayama (3405_CR18) 2019; 8
S Goyama (3405_CR133) 2015; 125
L Covassin (3405_CR112) 2013; 174
I Fichtner (3405_CR28) 2008; 14
G Ishii (3405_CR11) 2016; 99
M Vockerodt (3405_CR106) 2015; 235
WN Liu (3405_CR124) 2020; 12
DL Greiner (3405_CR136) 1995; 146
MD Thakur (3405_CR41) 2013; 494
J Chou (3405_CR75) 2013; 8
S Sivanand (3405_CR100) 2012; 4
W-S Lee (3405_CR72) 2014; 93
T Zhang (3405_CR104) 2015; 10
L Zhang (3405_CR105) 2015; 5
MQ McCreery (3405_CR117) 2017
NC Walsh (3405_CR60) 2017; 12
K Kalavska (3405_CR113) 2018; 40
YY Choi (3405_CR114) 2016; 6
JG Clohessy (3405_CR45) 2015; 12
J Merk (3405_CR26) 2009; 36
C Pauli (3405_CR47) 2017; 7
P Malaney (3405_CR48) 2014; 344
A Bertotti (3405_CR80) 2011; 1
L-C Yao (3405_CR24) 2019
J Johnson (3405_CR3) 2001; 84
MK Kim (3405_CR79) 2012; 11
E Fujii (3405_CR103) 2008; 58
MF Sanmamed (3405_CR51) 2015; 75
X Tian (3405_CR84) 2019; 448
H-J Hausser (3405_CR97) 2005; 333
Y Wang (3405_CR146) 2017
T Blunt (3405_CR134) 1995; 80
P De La Rochere (3405_CR33) 2018; 39
GJ Yoshida (3405_CR14) 2020; 13
S Laitinen (3405_CR96) 2002; 35
K Sprouffske (3405_CR108) 2020; 18
P Eirew (3405_CR70) 2015; 518
X Zhang (3405_CR126) 2013; 73
AT Byrne (3405_CR38) 2017; 17
S Corso (3405_CR36) 2018; 20
LA Petrillo (3405_CR107) 2012; 135
KM Brown (3405_CR9) 2016; 7
LD Shultz (3405_CR141) 2005; 174
F Pflumio (3405_CR139) 1996; 88
J-C Cutz (3405_CR65) 2006; 12
I Garrido-Laguna (3405_CR131) 2011; 17
E Richard (3405_CR140) 2016; 240
F Behbod (3405_CR21) 2009; 11
L de Plater (3405_CR68) 2010; 103
Y Liu (3405_CR118) 2015; 5
LD Shultz (3405_CR138) 1995; 154
W Tu (3405_CR32) 2016
K Jin (3405_CR101) 2011; 58
LM Ellis (3405_CR4) 2010; 16
A Staack (3405_CR90) 2003; 54
E Izumchenko (3405_CR8) 2017; 28
SB Keysar (3405_CR99) 2013; 7
A Ajith (3405_CR7) 2021; 12
KSM Yong (3405_CR31) 2018; 66
B Olson (3405_CR119) 2018; 8
T Helleday (3405_CR54) 2020; 31
Y Wang (3405_CR20) 2016; 91
H Ledford (3405_CR10) 2016; 530
X-C Zhang (3405_CR130) 2013; 11
C Grisanzio (3405_CR93) 2011; 225
F Ricci (3405_CR128) 2014; 74
K-G Huo (3405_CR30) 2020; 9
C Isella (3405_CR83) 2015; 47
C-P Day (3405_CR77) 2015; 163
NM Navone (3405_CR88) 2018; 78
C Wetterauer (3405_CR115) 2015; 75
NE Sharpless (3405_CR120) 2006; 5
H Jiang (3405_CR57) 2017; 8
3405_CR52
Y Jiang (3405_CR144) 2018; 16
3405_CR1
Y Zhao (3405_CR50) 2018; 67
M Ilie (3405_CR63) 2015; 4
S Kopetz (3405_CR49) 2015; 33
L Weiswald (3405_CR85) 2013; 108
E Marangoni (3405_CR125) 2007; 13
M Hidalgo (3405_CR37) 2014; 4
R Mhaidly (3405_CR56) 2020; 12
Y Wang (3405_CR91) 2005; 64
Y Zhao (3405_CR55) 2010; 70
AT Pearson (3405_CR123) 2016; 7
T Goto (3405_CR15) 2020; 10
D Wang (3405_CR62) 2017; 140
SJ Vidal (3405_CR92) 2015; 27
MR Simpson-Abelson (3405_CR27) 2008; 180
LE Dobrolecki (3405_CR19) 2016; 35
S Nik-Zainal (3405_CR66) 2016; 534
J Jung (3405_CR122) 2018; 50
YB Cho (3405_CR78) 2014; 187
CS Mullins (3405_CR82) 2019; 11
AM Razmara (3405_CR29) 2020; 37
T John (3405_CR25) 2011; 17
S Julien (3405_CR76) 2012; 18
YY Choi (3405_CR116) 2016; 6
L Hutchinson (3405_CR6) 2011; 8
S Nonoyama (3405_CR135) 1993; 150
Y Komohara (3405_CR12) 2017; 241
D-Y Oh (3405_CR35) 2020; 17
Y Zhang (3405_CR73) 2020; 50
A Rodriguez-Garcia (3405_CR58) 2020
H-M Lam (3405_CR89) 2018
M Read (3405_CR102) 2016; 23
KM Morgan (3405_CR143) 2017; 7
L Ny (3405_CR59) 2020; 31
P Lu (3405_CR13) 2011; 3
JW Cassidy (3405_CR71) 2015; 75
M Nunes (3405_CR127) 2015; 75
3405_CR39
C Liu (3405_CR64) 2020; 470
HM Nguyen (3405_CR87) 2017; 77
Y Maru (3405_CR42) 2019; 8
I Holen (3405_CR67) 2017; 10
SW Christianson (3405_CR137) 1996; 171
JS Boehm (3405_CR109) 2015; 16
J Steinestel (3405_CR95) 2019; 10
YS DeRose (3405_CR69) 2011; 17
GP Risbridger (3405_CR94) 2017
V Dangles-Marie (3405_CR81) 2007; 67
S Kopetz (3405_CR86) 2012; 18
S Du Manoir (3405_CR147) 2014; 8
3405_CR40
M Puchalapalli (3405_CR61) 2016; 11
T Kuwata (3405_CR145) 2019; 8
YJ Jung (3405_CR142) 2017; 18
I Puig (3405_CR74) 2013; 19
LMC Georges (3405_CR121) 2019; 6
R Rezaee (3405_CR5) 2017; 12
B Murphy (3405_CR98) 2016; 76
M Nehls (3405_CR132) 1994; 372
M Wang (3405_CR110) 2018; 32
M Gock (3405_CR23) 2016
3405_CR44
References_xml – volume: 50
  start-page: 1108
  issue: 10
  year: 2020
  ident: 3405_CR73
  publication-title: Jpn J Clin Oncol
  doi: 10.1093/jjco/hyaa089
– volume: 12
  start-page: 1915
  issue: 7
  year: 2020
  ident: 3405_CR56
  publication-title: Cancers
  doi: 10.3390/cancers12071915
– volume: 5
  start-page: 708
  issue: 5
  year: 2015
  ident: 3405_CR118
  publication-title: Quant Imaging Med Surg
– volume: 32
  start-page: 1537
  issue: 3
  year: 2018
  ident: 3405_CR110
  publication-title: FASEB J
  doi: 10.1096/fj.201700740R
– volume: 15
  start-page: S24
  issue: 2
  year: 2020
  ident: 3405_CR53
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2019.12.065
– volume: 8
  start-page: 505
  issue: 5
  year: 2019
  ident: 3405_CR42
  publication-title: Cells
  doi: 10.3390/cells8050505
– volume: 108
  start-page: 1720
  issue: 8
  year: 2013
  ident: 3405_CR85
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2013.132
– volume: 35
  start-page: 66
  issue: 1
  year: 2002
  ident: 3405_CR96
  publication-title: Genes Chromosom Cancer
  doi: 10.1002/gcc.10097
– volume: 9
  start-page: 1
  issue: 1
  year: 2019
  ident: 3405_CR46
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-48634-y
– volume: 58
  start-page: 559
  issue: 9
  year: 2008
  ident: 3405_CR103
  publication-title: Pathol Int
  doi: 10.1111/j.1440-1827.2008.02271.x
– volume: 103
  start-page: 1192
  issue: 8
  year: 2010
  ident: 3405_CR68
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6605900
– volume: 37
  start-page: 413
  issue: 3
  year: 2020
  ident: 3405_CR29
  publication-title: Clin Exp Metas
  doi: 10.1007/s10585-020-10033-3
– volume: 12
  start-page: 491
  issue: 8
  year: 2015
  ident: 3405_CR45
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2015.62
– volume: 13
  start-page: 4
  issue: 1
  year: 2020
  ident: 3405_CR14
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-019-0829-z
– volume: 7
  start-page: 462
  issue: 5
  year: 2017
  ident: 3405_CR47
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-16-1154
– volume: 13
  start-page: 3989
  issue: 13
  year: 2007
  ident: 3405_CR125
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-07-0078
– volume: 4
  start-page: 201
  issue: 2
  year: 2015
  ident: 3405_CR63
  publication-title: Cancer Med
  doi: 10.1002/cam4.357
– volume: 10
  issue: 7
  year: 2015
  ident: 3405_CR104
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0134493
– year: 2020
  ident: 3405_CR58
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01109/full
– start-page: 157
  volume-title: Suppression and regulation of immune responses
  year: 2016
  ident: 3405_CR32
  doi: 10.1007/978-1-4939-3139-2_10
– volume: 235
  start-page: 312
  issue: 2
  year: 2015
  ident: 3405_CR106
  publication-title: J Pathol
  doi: 10.1002/path.4459
– volume: 39
  start-page: 748
  issue: 9
  year: 2018
  ident: 3405_CR33
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2018.07.001
– volume: 5
  start-page: 9447
  year: 2015
  ident: 3405_CR105
  publication-title: Sci Rep
  doi: 10.1038/srep09447
– volume: 11
  start-page: R66
  issue: 5
  year: 2009
  ident: 3405_CR21
  publication-title: Breast Cancer Res
  doi: 10.1186/bcr2358
– volume: 12
  start-page: 2301
  year: 2021
  ident: 3405_CR7
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.687715
– volume: 163
  start-page: 39
  issue: 1
  year: 2015
  ident: 3405_CR77
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.068
– volume: 171
  start-page: 186
  issue: 2
  year: 1996
  ident: 3405_CR137
  publication-title: Cell Immunol
  doi: 10.1006/cimm.1996.0193
– volume: 470
  start-page: 95
  year: 2020
  ident: 3405_CR64
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2019.10.027
– volume: 88
  start-page: 3731
  issue: 10
  year: 1996
  ident: 3405_CR139
  publication-title: Blood
  doi: 10.1182/blood.V88.10.3731.bloodjournal88103731
– volume: 140
  start-page: 662
  issue: 3
  year: 2017
  ident: 3405_CR62
  publication-title: Int J Cancer
  doi: 10.1002/ijc.30472
– volume: 154
  start-page: 180
  issue: 1
  year: 1995
  ident: 3405_CR138
  publication-title: J Immunol
  doi: 10.4049/jimmunol.154.1.180
– volume: 64
  start-page: 149
  issue: 2
  year: 2005
  ident: 3405_CR91
  publication-title: Prostate
  doi: 10.1002/pros.20225
– volume: 74
  start-page: 6980
  issue: 23
  year: 2014
  ident: 3405_CR128
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-14-0274
– ident: 3405_CR44
  doi: 10.1158/2159-8290.CD-11-0061
– volume: 78
  start-page: 1262
  issue: 16
  year: 2018
  ident: 3405_CR88
  publication-title: Prostate
  doi: 10.1002/pros.23701
– volume: 58
  start-page: 1814
  issue: 110–111
  year: 2011
  ident: 3405_CR101
  publication-title: Hepatogastroenterology
– volume: 75
  start-page: 3466
  issue: 17
  year: 2015
  ident: 3405_CR51
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-14-3510
– volume: 12
  start-page: 187
  year: 2017
  ident: 3405_CR60
  publication-title: Annu Rev Pathol
  doi: 10.1146/annurev-pathol-052016-100332
– volume: 225
  start-page: 212
  issue: 2
  year: 2011
  ident: 3405_CR93
  publication-title: J Pathol
  doi: 10.1002/path.2929
– volume: 125
  start-page: 2630
  issue: 17
  year: 2015
  ident: 3405_CR133
  publication-title: Blood J Am Soc Hematol
– volume: 91
  start-page: 15
  issue: 4–5
  year: 2016
  ident: 3405_CR20
  publication-title: Differentiation
  doi: 10.1016/j.diff.2015.10.012
– volume: 11
  start-page: 1500
  issue: 7
  year: 2012
  ident: 3405_CR79
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-11-0937
– volume: 146
  start-page: 888
  issue: 4
  year: 1995
  ident: 3405_CR136
  publication-title: Am J Pathol
– volume: 8
  start-page: 1358
  issue: 11
  year: 2018
  ident: 3405_CR119
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-18-0044
– volume: 67
  start-page: 1845
  issue: 10
  year: 2018
  ident: 3405_CR50
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-315201
– volume: 33
  start-page: 4032
  issue: 34
  year: 2015
  ident: 3405_CR49
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2015.63.2497
– volume: 12
  start-page: 237
  issue: 3
  year: 2017
  ident: 3405_CR5
  publication-title: Expert Opin Drug Discov
  doi: 10.1080/17460441.2017.1281245
– volume: 8
  start-page: 926
  issue: 12
  year: 2017
  ident: 3405_CR57
  publication-title: Protein Cell
  doi: 10.1007/s13238-017-0472-9
– volume: 8
  start-page: 585
  issue: 6
  year: 2019
  ident: 3405_CR145
  publication-title: Cells
  doi: 10.3390/cells8060585
– volume: 8
  issue: 11
  year: 2013
  ident: 3405_CR75
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0079874
– volume: 93
  issue: 28
  year: 2014
  ident: 3405_CR72
  publication-title: Medicine
  doi: 10.1097/MD.0000000000000298
– volume: 67
  start-page: 398
  issue: 1
  year: 2007
  ident: 3405_CR81
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-06-0594
– volume: 12
  start-page: 473
  issue: 7
  year: 2010
  ident: 3405_CR22
  publication-title: Clin Transl Oncol
  doi: 10.1007/s12094-010-0540-6
– volume: 17
  start-page: 33
  issue: 1
  year: 2020
  ident: 3405_CR35
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-019-0268-3
– volume: 9
  start-page: 2214
  issue: 5
  year: 2020
  ident: 3405_CR30
  publication-title: Transl Lung Cancer Res
  doi: 10.21037/tlcr-20-154
– volume: 20
  start-page: 443
  issue: 5
  year: 2018
  ident: 3405_CR36
  publication-title: Neoplasia
  doi: 10.1016/j.neo.2018.02.003
– volume: 10
  start-page: 359
  issue: 4
  year: 2017
  ident: 3405_CR67
  publication-title: Dis Model Mech
  doi: 10.1242/dmm.028274
– volume: 7
  start-page: 776
  issue: 4
  year: 2013
  ident: 3405_CR99
  publication-title: Mol Oncol
  doi: 10.1016/j.molonc.2013.03.004
– volume: 4
  start-page: 998
  issue: 9
  year: 2014
  ident: 3405_CR37
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-14-0001
– volume: 12
  start-page: 4043
  issue: 13
  year: 2006
  ident: 3405_CR65
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-06-0252
– volume: 518
  start-page: 422
  issue: 7539
  year: 2015
  ident: 3405_CR70
  publication-title: Nature
  doi: 10.1038/nature13952
– volume: 54
  start-page: 212
  issue: 3
  year: 2003
  ident: 3405_CR90
  publication-title: Prostate
  doi: 10.1002/pros.10179
– start-page: 868
  volume-title: The house mouse as a laboratory model: a historical perspective. The Laboratory Mouse
  year: 2012
  ident: 3405_CR2
– volume: 18
  start-page: e99
  issue: 2
  year: 2017
  ident: 3405_CR142
  publication-title: Clin Lung Cancer
  doi: 10.1016/j.cllc.2016.09.012
– volume: 3
  issue: 12
  year: 2011
  ident: 3405_CR13
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a005058
– volume: 174
  start-page: 372
  issue: 3
  year: 2013
  ident: 3405_CR112
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12180
– volume: 7
  start-page: 66212
  issue: 40
  year: 2016
  ident: 3405_CR9
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.11184
– volume: 17
  start-page: 1514
  issue: 11
  year: 2011
  ident: 3405_CR69
  publication-title: Nat Med
  doi: 10.1038/nm.2454
– volume: 80
  start-page: 813
  issue: 5
  year: 1995
  ident: 3405_CR134
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90360-7
– volume: 150
  start-page: 3817
  issue: 9
  year: 1993
  ident: 3405_CR135
  publication-title: J Immunol
  doi: 10.4049/jimmunol.150.9.3817
– volume: 530
  start-page: 391
  issue: 7591
  year: 2016
  ident: 3405_CR10
  publication-title: Nature
  doi: 10.1038/nature.2016.19364
– volume: 66
  start-page: 245
  issue: 4
  year: 2018
  ident: 3405_CR31
  publication-title: Arch Immunol Ther Exp
  doi: 10.1007/s00005-018-0506-x
– volume: 1
  start-page: 508
  issue: 6
  year: 2011
  ident: 3405_CR80
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-11-0109
– volume: 76
  start-page: 5798
  issue: 19
  year: 2016
  ident: 3405_CR98
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-16-0122
– volume: 8
  start-page: 431
  issue: 2
  year: 2014
  ident: 3405_CR147
  publication-title: Mol Oncol
  doi: 10.1016/j.molonc.2013.11.010
– volume: 187
  start-page: 502
  issue: 2
  year: 2014
  ident: 3405_CR78
  publication-title: J Surg Res
  doi: 10.1016/j.jss.2013.11.010
– volume: 240
  start-page: 256
  issue: 3
  year: 2016
  ident: 3405_CR140
  publication-title: J Pathol
  doi: 10.1002/path.4772
– volume: 14
  start-page: 6456
  issue: 20
  year: 2008
  ident: 3405_CR28
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-08-0138
– volume: 372
  start-page: 103
  issue: 6501
  year: 1994
  ident: 3405_CR132
  publication-title: Nature
  doi: 10.1038/372103a0
– volume: 36
  start-page: 454
  issue: 3
  year: 2009
  ident: 3405_CR26
  publication-title: Eur J Cardiothorac Surg
  doi: 10.1016/j.ejcts.2009.03.054
– volume: 174
  start-page: 6477
  issue: 10
  year: 2005
  ident: 3405_CR141
  publication-title: J Immunol
  doi: 10.4049/jimmunol.174.10.6477
– volume: 77
  start-page: 654
  issue: 6
  year: 2017
  ident: 3405_CR87
  publication-title: Prostate
  doi: 10.1002/pros.23313
– volume: 7
  start-page: 7993
  issue: 7
  year: 2016
  ident: 3405_CR123
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6919
– volume: 12
  start-page: 1025
  issue: 4
  year: 2020
  ident: 3405_CR124
  publication-title: Cancers
  doi: 10.3390/cancers12041025
– volume: 494
  start-page: 251
  issue: 7436
  year: 2013
  ident: 3405_CR41
  publication-title: Nature
  doi: 10.1038/nature11814
– volume: 7
  start-page: 2
  year: 2017
  ident: 3405_CR143
  publication-title: Front Oncol
  doi: 10.3389/fonc.2017.00002
– volume: 16
  start-page: 138
  issue: 1
  year: 2018
  ident: 3405_CR144
  publication-title: J Transl Med
  doi: 10.1186/s12967-018-1516-5
– volume: 344
  start-page: 1
  issue: 1
  year: 2014
  ident: 3405_CR48
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2013.10.010
– ident: 3405_CR1
– volume: 5
  start-page: 741
  issue: 9
  year: 2006
  ident: 3405_CR120
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd2110
– volume: 27
  start-page: 223
  issue: 2
  year: 2015
  ident: 3405_CR92
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2014.11.013
– volume: 11
  start-page: 1520
  issue: 10
  year: 2019
  ident: 3405_CR82
  publication-title: Cancers
  doi: 10.3390/cancers11101520
– volume: 75
  start-page: 585
  issue: 6
  year: 2015
  ident: 3405_CR115
  publication-title: Prostate
  doi: 10.1002/pros.22939
– volume: 17
  start-page: 5793
  issue: 17
  year: 2011
  ident: 3405_CR131
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-0341
– volume: 18
  start-page: 323
  year: 2020
  ident: 3405_CR108
  publication-title: Comput Struct Biotechnol J
  doi: 10.1016/j.csbj.2020.01.008
– volume: 47
  start-page: 312
  issue: 4
  year: 2015
  ident: 3405_CR83
  publication-title: Nat Genet
  doi: 10.1038/ng.3224
– volume-title: Patient-derived xenograft models of human cancer
  year: 2017
  ident: 3405_CR146
  doi: 10.1007/978-3-319-55825-7
– volume: 21
  start-page: 1318
  issue: 11
  year: 2015
  ident: 3405_CR34
  publication-title: Nat Med
  doi: 10.1038/nm.3954
– volume: 18
  start-page: 5314
  issue: 19
  year: 2012
  ident: 3405_CR76
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-12-0372
– volume: 28
  start-page: 2595
  issue: 10
  year: 2017
  ident: 3405_CR8
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdx416
– volume: 6
  start-page: 22172
  year: 2016
  ident: 3405_CR116
  publication-title: Sci Rep
  doi: 10.1038/srep22172
– volume: 18
  start-page: 5160
  issue: 19
  year: 2012
  ident: 3405_CR86
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-12-2408
– volume: 11
  issue: 9
  year: 2016
  ident: 3405_CR61
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0163521
– volume: 6
  start-page: 139
  year: 2019
  ident: 3405_CR121
  publication-title: Front Med
  doi: 10.3389/fmed.2019.00139
– ident: 3405_CR40
– volume: 36
  start-page: 1
  issue: 1
  year: 2020
  ident: 3405_CR111
  publication-title: Lab Anim Res
  doi: 10.1186/s42826-020-00045-1
– volume: 19
  start-page: 6787
  issue: 24
  year: 2013
  ident: 3405_CR74
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-12-1740
– volume: 11
  start-page: 168
  issue: 1
  year: 2013
  ident: 3405_CR130
  publication-title: J Transl Med
  doi: 10.1186/1479-5876-11-168
– volume: 99
  start-page: 186
  year: 2016
  ident: 3405_CR11
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2015.07.007
– volume: 8
  start-page: 889
  issue: 8
  year: 2019
  ident: 3405_CR17
  publication-title: Cells
  doi: 10.3390/cells8080889
– volume: 34
  start-page: 132
  issue: 1
  year: 2015
  ident: 3405_CR129
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-015-0243-5
– volume: 40
  start-page: 3593
  issue: 6
  year: 2018
  ident: 3405_CR113
  publication-title: Oncol Rep
– volume: 451
  start-page: 345
  issue: 7176
  year: 2008
  ident: 3405_CR43
  publication-title: Nature
  doi: 10.1038/nature06489
– volume: 448
  start-page: 20
  year: 2019
  ident: 3405_CR84
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2019.01.031
– volume: 17
  start-page: 134
  issue: 1
  year: 2011
  ident: 3405_CR25
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-10-2224
– volume: 31
  start-page: 167
  issue: 2
  year: 2020
  ident: 3405_CR54
  publication-title: Ann Oncol
  doi: 10.1016/j.annonc.2019.11.007
– volume: 75
  start-page: 2963
  issue: 15
  year: 2015
  ident: 3405_CR71
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-15-0727
– volume: 6
  start-page: 1
  issue: 1
  year: 2016
  ident: 3405_CR114
  publication-title: Sci Rep
  doi: 10.1038/s41598-016-0001-8
– start-page: 241
  volume-title: Target identification and validation in drug discovery
  year: 2019
  ident: 3405_CR24
  doi: 10.1007/978-1-4939-9145-7_15
– volume: 8
  start-page: 189
  issue: 4
  year: 2011
  ident: 3405_CR6
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2011.34
– volume: 16
  start-page: 373
  issue: 7
  year: 2015
  ident: 3405_CR109
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3967
– volume: 23
  start-page: 305
  issue: 1
  year: 2016
  ident: 3405_CR102
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-015-4425-3
– volume: 135
  start-page: 913
  issue: 3
  year: 2012
  ident: 3405_CR107
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-012-2226-y
– volume: 73
  start-page: 4885
  issue: 15
  year: 2013
  ident: 3405_CR126
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-12-4081
– ident: 3405_CR39
– volume: 70
  start-page: 9053
  issue: 22
  year: 2010
  ident: 3405_CR55
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-10-2880
– volume: 10
  start-page: 4213
  issue: 41
  year: 2019
  ident: 3405_CR95
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3925
– volume: 31
  start-page: 266
  issue: 2
  year: 2020
  ident: 3405_CR59
  publication-title: Ann Oncol
  doi: 10.1016/j.annonc.2019.11.002
– volume: 180
  start-page: 7009
  issue: 10
  year: 2008
  ident: 3405_CR27
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.10.7009
– year: 2016
  ident: 3405_CR23
  publication-title: BioMed Res Int
  doi: 10.1155/2016/1715053
– start-page: 1
  volume-title: Prostate cancer
  year: 2018
  ident: 3405_CR89
– volume: 50
  start-page: 1
  issue: 1
  year: 2018
  ident: 3405_CR122
  publication-title: Cancer Res Treat
  doi: 10.4143/crt.2017.307
– volume: 4
  start-page: 137ra75
  issue: 137
  year: 2012
  ident: 3405_CR100
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3003643
– volume: 75
  start-page: 1560
  issue: 8
  year: 2015
  ident: 3405_CR127
  publication-title: Can Res
  doi: 10.1158/0008-5472.CAN-14-1590
– year: 2017
  ident: 3405_CR117
  publication-title: Annu Rev Cancer Biol
  doi: 10.1146/annurev-cancerbio-050216-122002
– volume: 333
  start-page: 216
  issue: 1
  year: 2005
  ident: 3405_CR97
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2005.05.097
– volume: 35
  start-page: 547
  issue: 4
  year: 2016
  ident: 3405_CR19
  publication-title: Cancer Metastasis Rev
  doi: 10.1007/s10555-016-9653-x
– volume: 534
  start-page: 47
  issue: 7605
  year: 2016
  ident: 3405_CR66
  publication-title: Nature
  doi: 10.1038/nature17676
– volume: 8
  start-page: 621
  issue: 6
  year: 2019
  ident: 3405_CR18
  publication-title: Cells
  doi: 10.3390/cells8060621
– volume: 9
  start-page: 338
  issue: 6
  year: 2012
  ident: 3405_CR16
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2012.61
– volume: 10
  start-page: 64
  issue: 3
  year: 2020
  ident: 3405_CR15
  publication-title: J Pers Med
  doi: 10.3390/jpm10030064
– start-page: 11
  volume-title: Patient-derived xenograft models of human cancer
  year: 2017
  ident: 3405_CR94
  doi: 10.1007/978-3-319-55825-7_2
– volume: 84
  start-page: 1424
  issue: 10
  year: 2001
  ident: 3405_CR3
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2001.1796
– volume: 16
  start-page: 974
  issue: 9
  year: 2010
  ident: 3405_CR4
  publication-title: Nat Med
  doi: 10.1038/nm0910-974
– ident: 3405_CR52
  doi: 10.1158/2326-6066.IMM2016-B126
– volume: 241
  start-page: 313
  issue: 3
  year: 2017
  ident: 3405_CR12
  publication-title: J Pathol
  doi: 10.1002/path.4824
– volume: 17
  start-page: 254
  issue: 4
  year: 2017
  ident: 3405_CR38
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc.2016.140
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Snippet The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies....
Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical...
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SubjectTerms Animal models in research
Animals
Antitumor agents
Avatar model of cancer
Cancer
Cancer animal model
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
COVID-19
Disease Models, Animal
Drug development
Drugs
Gene expression
Heterografts
Humanized model
Humans
Immune system
Immunotherapy
Medical research
Neoplasms - pathology
Patient outcomes
Patients
PDX
Precision medicine
Precision Medicine - methods
Preclinical study
Prevention
Review
Success
Transplants & implants
Tumor Microenvironment
Tumors
Validity
Xenograft Model Antitumor Assays
Xenografts
Xenotransplantation
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Title Patient-derived xenograft (PDX) models, applications and challenges in cancer research
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