Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)

• Published in: Biology of sex differences Vol. 14; no. 1; pp. 21 - 13
• Main Authors: Escobar-Morreale, Héctor F., Martínez-García, M. Ángeles, Insenser, María, Cañellas, Nicolau, Correig, Xavier, Luque-Ramírez, Manuel
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.04.2023; BioMed Central; BMC
• Subjects: Androgens; Body fat; Body mass index; Carbohydrates; Comorbidity; Estrogens; Female; Humans; Insulin resistance; Magnetic Resonance Spectroscopy; Male; Metabolism; Metabolites; Metabolomics; NMR; Nuclear magnetic resonance; Nuclear magnetic resonance spectroscopy; Obesity; Obesity - metabolism; Ovaries; Physiological aspects; Polycystic Ovary Syndrome; Protons; Sex; Sex Characteristics; Sex hormones; Sexual dimorphism; Stein-Leventhal syndrome; Type 2 diabetes; Young Adult; Young adults; Germany; Obesity; Polycystic ovary syndrome; Androgens; Metabolism; Estrogens; Sex

The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonance spectroscopy metabolomics profiling, that androgen excess in women induces also a certain...