PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

• Published in: Journal of neuroinflammation Vol. 17; no. 1; pp. 140 - 17
• Main Authors: Shrestha, Stal, Kim, Min-Jeong, Eldridge, Mark, Lehmann, Michael L., Frankland, Michael, Liow, Jeih-San, Yu, Zu-Xi, Cortes-Salva, Michelle, Telu, Sanjay, Henter, Ioline D., Gallagher, Evan, Lee, Jae-Hoon, Fredericks, J. Megan, Poffenberger, Chelsie, Tye, George, Ruiz-Perdomo, Yanira, Anaya, Fernanda Juarez, Montero Santamaria, Jose A., Gladding, Robert L., Zoghbi, Sami S., Fujita, Masahiro, Katz, James D., Pike, Victor W., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.05.2020; BioMed Central; BMC
• Subjects: Adult; Animals; Arthritis, Rheumatoid - diagnostic imaging; Brain; Brain - diagnostic imaging; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 - analysis; Cyclooxygenases; Diagnosis; Electrocardiography; Enzymes; Female; Glucose; Humans; Inflammation; Inflammation - diagnostic imaging; Injection; Joint diseases; Laboratory animals; Lipopolysaccharide; Lipopolysaccharides; Macaca mulatta; Measurement; Metabolism; Methods; Middle Aged; Neuroimaging; Nonsteroidal anti-inflammatory drugs; Positron emission tomography; Positron-Emission Tomography - methods; Prostaglandins; Proteins; Putamen; Pyrimidines; Radioisotopes; Radioligand assay; Radiopharmaceuticals; Rheumatoid arthritis; Studies; Transcription; Up-regulation; United States; Lipopolysaccharide; Inflammation; Positron emission tomography; Cyclooxygenase 2; Rheumatoid arthritis; Cyclooxygenase 1

Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for...