PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study - Shrestha, Stal; Kim, Min-Jeong; Eldridge, Mark; Lehmann, Michael L.; Frankland, Michael; Liow, Jeih-San; Yu, Zu-Xi; Cortes-Salva, Michelle; Telu, Sanjay; Henter, Ioline D.; Gallagher, Evan; Lee, Jae-Hoon; et al. (Journal of neuroinflammation, 2020)
Keywords: Adult; Animals; Arthritis, Rheumatoid - diagnostic imaging; Brain; Brain - diagnostic imaging; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 - analysis; Cyclooxygenases; Diagnosis; Electrocardiography; Enzymes; Female; Glucose; Humans; Inflammation; Inflammation - diagnostic imaging; Injection; Joint diseases; Laboratory animals; Lipopolysaccharide; Lipopolysaccharides; Macaca mulatta; Measurement; Metabolism; Methods; Middle Aged; Neuroimaging; Nonsteroidal anti-inflammatory drugs; Positron emission tomography; Positron-Emission Tomography - methods; Prostaglandins; Proteins; Putamen; Pyrimidines; Radioisotopes; Radioligand assay; Radiopharmaceuticals; Rheumatoid arthritis; Studies; Transcription; Up-regulation; United States; Lipopolysaccharide; Inflammation; Positron emission tomography; Cyclooxygenase 2; Rheumatoid arthritis; Cyclooxygenase 1