Radiation-induced lung injury: current evidence

• Published in: BMC pulmonary medicine Vol. 21; no. 1; pp. 9 - 12
• Main Authors: Arroyo-Hernández, Marisol, Maldonado, Federico, Lozano-Ruiz, Francisco, Muñoz-Montaño, Wendy, Nuñez-Baez, Mónica, Arrieta, Oscar
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2021; BioMed Central; BMC
• Subjects: Adverse events; Antineoplastic agents; Cancer therapies; Chemotherapy; Chronic obstructive pulmonary disease; Corticosteroids; Cytotoxicity; Disease; Drug therapy; Fibrosis; Histology; Immunotherapy; Lung cancer; Lung diseases; Lungs; Mortality; Oxidative stress; Patients; Pneumonitis; Prevention; Prophylaxis; Pulmonology; Radiation injuries; Radiation pneumonitis; Radiation therapy; Radiation-induced lung injury; Radiotherapy; Respiratory function; Review; Risk factors; Smoking; Thorax; Mexico; Pneumonitis; Lung cancer; Radiation-induced lung injury; Adverse effects; Antineoplastic agents; Radiotherapy; Radiation pneumonitis

Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard treatments for various thoracic malignancies; however, adverse pulmonary effects, like pneumonitis, can be life-threatening. Pneumonitis is caused by direct cytotoxic effect, oxidative stress, and immune-mediated...