Salivary 8-hydroxy-2′-deoxyguanosine levels in patients with oral cancer: a systematic review and meta-analysis

• Published in: BMC cancer Vol. 24; no. 1; pp. 960 - 9
• Main Authors: Alarcón-Sánchez, Mario Alberto, Escoto-Vasquez, Lilibeth-Stephania, Heboyan, Artak
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.08.2024; BioMed Central; BMC
• Subjects: 8-Hydroxy-2'-Deoxyguanosine - analysis; 8-Hydroxy-2'-Deoxyguanosine - metabolism; 8-hydroxy-2′-deoxyguanosine; 8-Hydroxydeoxyguanosine; Bibliometrics; Biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Biopsy; Deoxyguanosine; Deoxyribonucleotides; Development and progression; DNA damage; Enzymes; Genetic aspects; Head & neck cancer; Health aspects; Health care; Humans; Measurement; Meta-analysis; Mouth cancer; Mouth Neoplasms - diagnosis; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Mutagenesis; Oral cancer; Oxidative Stress; Physiological aspects; Saliva; Saliva - chemistry; Saliva - metabolism; Software; Squamous cell carcinoma; Squamous cell carcinoma of head and neck; Statistical analysis; Systematic review; Mexico; United States > US; Biomarkers; 8-hydroxy-2′-deoxyguanosine; Squamous cell carcinoma of head and neck; Saliva

DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim of this study was to evaluate and compare salivary levels of the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with oral cancer (OC) compared to the c...