Sulphonylurea usage in melioidosis is associated with severe disease and suppressed immune response

• Published in: PLoS neglected tropical diseases Vol. 8; no. 4; p. e2795
• Main Authors: Liu, Xiang, Foo, Geraldine, Lim, Wan Peng, Ravikumar, Sharada, Sim, Siew Hoon, Win, Mar Soe, Goh, Jessamine Geraldine, Lim, Joan Hui Juan, Ng, Ying Hui, Fisher, Dale, Khoo, Chin Meng, Tan, Gladys, Chai, Louis Yi Ann
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Asia, Southeastern; Australia; Bacillus; Biology and Life Sciences; Burkholderia pseudomallei; Care and treatment; Cohort Studies; Diabetes; Diabetes Complications - epidemiology; Diabetes Mellitus - drug therapy; Disease susceptibility; Female; Health aspects; Hospitals; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - therapeutic use; Immune response; Infections; Length of Stay; Male; Medicine and Health Sciences; Melioidosis - complications; Melioidosis - immunology; Melioidosis - mortality; Melioidosis - pathology; Middle Aged; Mortality; Pseudomonas infections; Retrospective Studies; Risk factors; Sepsis - mortality; Sepsis - pathology; Studies; Sulfonylurea Compounds - adverse effects; Sulfonylurea Compounds - therapeutic use; Surface water; Survival Analysis; Treatment Outcome; Asia, Southeastern; Australia; Length of Stay; Diabetes Complications; Humans; Middle Aged; Male; Treatment Outcome; Diabetes Mellitus; Asia, Southeastern; Melioidosis; Hypoglycemic Agents; Survival Analysis; Female; Sepsis; Retrospective Studies; Sulfonylurea Compounds; Australia; Cohort Studies

Melioidosis is a problem in the developing tropical regions of Southeast Asia and Northern Australia where the the Gram negative saprophytic bacillus Burkholderia pseudomallei is endemic with the risk of fulminant septicaemia. While diabetes mellitus is a well-established risk factor for melioidiosi...