Tauopathies: new perspectives and challenges

Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms...

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Published inMolecular neurodegeneration Vol. 17; no. 1; pp. 28 - 29
Main Authors Zhang, Yi, Wu, Kai-Min, Yang, Liu, Dong, Qiang, Yu, Jin-Tai
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 07.04.2022
BioMed Central
BMC
Subjects
Age
Alzheimer's disease
Aphasia
Autopsies
Behavior
Biomarkers
Cerebrospinal fluid
Chronic traumatic encephalopathy
Cognitive ability
Dementia
Development and progression
Epidemiology
Genetics
Humans
Inclusion bodies
Inclusion Bodies - metabolism
Isoforms
Movement disorders
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neuronal-glial interactions
Neurons - metabolism
Pathology
Phenotypes
Phosphorylation
Physiology
Protein Isoforms - genetics
Proteins
Review
Tau protein
tau Proteins - metabolism
Tauopathies
Tauopathies - metabolism
Therapeutics
Tauopathies
Biomarkers
Genetics
Neurodegeneration
Therapeutics
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Abstract Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics. Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
AbstractList Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics. Conclusions Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics. Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions.BACKGROUNDTauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions.Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics.MAIN BODYClinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics.Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.CONCLUSIONSSince tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics. Conclusions Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies. Keywords: Tauopathies, Neurodegeneration, Biomarkers, Therapeutics, Genetics
Abstract Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics. Conclusions Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
ArticleNumber 28
Audience Academic
Author Zhang, Yi
Yang, Liu
Dong, Qiang
Wu, Kai-Min
Yu, Jin-Tai
Author_xml – sequence: 1
  givenname: Yi
  surname: Zhang
  fullname: Zhang, Yi
– sequence: 2
  givenname: Kai-Min
  surname: Wu
  fullname: Wu, Kai-Min
– sequence: 3
  givenname: Liu
  surname: Yang
  fullname: Yang, Liu
– sequence: 4
  givenname: Qiang
  surname: Dong
  fullname: Dong, Qiang
– sequence: 5
  givenname: Jin-Tai
  orcidid: 0000-0002-7686-0547
  surname: Yu
  fullname: Yu, Jin-Tai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35392986$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Tauopathies
Biomarkers
Genetics
Neurodegeneration
Therapeutics
Language English
License 2022. The Author(s).
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Snippet Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Clinically, tauopathies can present with...
Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically,...
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Since tauopathies are still untreatable...
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions.BACKGROUNDTauopathies are a class of...
Abstract Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body...
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StartPage 28
SubjectTerms Age
Alzheimer's disease
Aphasia
Autopsies
Behavior
Biomarkers
Cerebrospinal fluid
Chronic traumatic encephalopathy
Cognitive ability
Dementia
Development and progression
Epidemiology
Genetics
Humans
Inclusion bodies
Inclusion Bodies - metabolism
Isoforms
Movement disorders
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neuronal-glial interactions
Neurons - metabolism
Pathology
Phenotypes
Phosphorylation
Physiology
Protein Isoforms - genetics
Proteins
Review
Tau protein
tau Proteins - metabolism
Tauopathies
Tauopathies - metabolism
Therapeutics
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Title Tauopathies: new perspectives and challenges
URI https://www.ncbi.nlm.nih.gov/pubmed/35392986
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https://pubmed.ncbi.nlm.nih.gov/PMC8991707
https://doaj.org/article/6a921e3ae16a45beb64175c5d8ad8ba2
Volume 17
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