Identifies KCTD5 as a novel cancer biomarker associated with programmed cell death and chemotherapy drug sensitivity

• Published in: BMC cancer Vol. 23; no. 1; pp. 408 - 17
• Main Authors: Shi, Yuan-Xiang, Yan, Jian-Hua, Liu, Wen, Deng, Jun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.05.2023; BioMed Central; BMC
• Subjects: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Analysis; Antitumor agents; Apoptosis; Apoptosis - genetics; Bcl-x protein; Biological markers; Biomarkers; Biomarkers, Tumor - genetics; Brain cancer; Cancer; Care and treatment; Cell apoptosis; Cell death; Chemotherapy; Colorectal cancer; Correlation analysis; Diagnosis; DNA methylation; Drug sensitivity; Fibroblasts; Flow cytometry; Gene expression; Gene set enrichment analysis; Genetic aspects; Health aspects; Humans; Immunosuppressive agents; KCTD5; Lung cancer; Lung Neoplasms; Mcl-1 protein; Medical prognosis; Metastases; Metastasis; Microenvironments; Mutation; Necroptosis; Pan-cancer; Patient outcomes; Potassium; Potassium Channels; Prognosis; Protein expression; Proteins; Tumor microenvironment; Tumor Microenvironment - genetics; Tumors; China; Prognosis; Tumor microenvironment; Pan-cancer; KCTD5; Drug sensitivity; Cell apoptosis

More and more studies have demonstrated that potassium channel tetramerization domain-containing 5 (KCTD5) plays an important role in the development of cancer, but there is a lack of comprehensive research on the biological function of this protein in pan-cancer. This study systematically analyzed...