Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors - Qin, Ningbo; Sasaki, Tatsunori; Li, Wei; Wang, Jian; Zhang, Xiangyu; Li, Dahong; Li, Zhanlin; Cheng, Maosheng; Hua, Huiming; Koike, Kazuo (Journal of Enzyme Inhibition and Medicinal Chemistry, 2018)
Keywords: Asteraceae; Asteraceae - chemistry; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Inhibitors - analysis; Enzyme Inhibitors - pharmacology; flavonolignan; Flavonolignans; Flavonolignans - analysis; Flavonolignans - pharmacology; Humans; isosilybin; Molecular Docking Simulation; Molecular Structure; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism; Research Paper; RM1-950; Seeds; Seeds - chemistry; silybin; Silybum marianum; Structure-Activity Relationship; Therapeutics. Pharmacology; Protein tyrosine phosphatase 1B; flavonolignan; Silybum marianum; isosilybin; silybin