Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension

• Published in: Respiratory research Vol. 23; no. 1; pp. 6 - 18
• Main Authors: Guo, Mingzhou, Zhang, Mengzhe, Cao, Xiaopei, Fang, Xiaoyu, Li, Ke, Qin, Lu, He, Yuanzhou, Zhao, Jianping, Xu, Yongjian, Liu, Xiansheng, Li, Xiaochen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.01.2022; BioMed Central; BMC
• Subjects: Antibodies; Apoptosis; Blood pressure; Care and treatment; Cell adhesion & migration; Cell cycle; Cell growth; Cell migration; Cell proliferation; Cell surface; Cell viability; Chronic obstructive pulmonary disease; Diagnosis; Extracellular signal-regulated kinase; Health aspects; Heart; Human pulmonary arterial smooth muscle cells; Hypertension; Hypertrophy; Hypoxia; Hypoxic pulmonary hypertension; Immunoprecipitation; Kinases; Lung diseases; Lungs; MAP kinase; Medical prognosis; Membrane proteins; Mitogen-activated protein kinase; mRNA; Muscles; Notch4; Phosphorylation; Proteins; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; Reagents; RNA-mediated interference; Signal transduction; Signaling; siRNA; Smooth muscle; Systolic pressure; Therapeutic targets; Ventricle; Western blotting; China; United States > US; Japan; Notch4; Mitogen-activated protein kinase; Human pulmonary arterial smooth muscle cells; Hypoxic pulmonary hypertension

Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced disorder pathologically characterized by pulmonary vascular remodeling. Notch4 as a cell surface receptor is critical for vascular development. However, little is known about the role and mechanism of Notch4 in the development of...