Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis

• Published in: Molecular cancer Vol. 20; no. 1; pp. 93 - 21
• Main Authors: Guo, Yaxin, Guo, Yuying, Chen, Chen, Fan, Dandan, Wu, Xiaoke, Zhao, Luyang, Shao, Bo, Sun, Zhenqiang, Ji, Zhenyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.06.2021; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Angiogenesis; Animals; Biomarkers; Cell proliferation; circ3823; Colorectal cancer; Colorectal cancer (CRC); Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Cytogenetics; Development and progression; Disease Progression; DNA sequencing; Female; Fluorescence in situ hybridization; Gene Expression Regulation, Neoplastic - genetics; Growth; Heterografts; Humans; Immunoprecipitation; Male; Medical research; Medicine, Experimental; Metastases; Metastasis; Methyltransferases; Mice; Mice, Inbred BALB C; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Myc protein; N6-methyladenosine; N6-methyladenosine (m6A); Neoplasm Invasiveness - genetics; Neovascularization, Pathologic - genetics; Next-generation sequencing; Nucleotide sequencing; Patients; Proteins; Ribonuclease; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Circular - metabolism; Signal Transduction - genetics; T Cell Transcription Factor 1 - genetics; T Cell Transcription Factor 1 - metabolism; Tumors; Tumour progression; Massachusetts; Japan; China; Beijing China; United States > US; Tumour progression; Angiogenesis; N6-methyladenosine (m6A); circ3823; Colorectal cancer (CRC)

Colorectal cancer (CRC) is one of the most common malignant tumours. The recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis is an extremely important cause of tumour growth and metastasis. Circular RNAs (circRNAs) have been emerged as vital regulators for t...