Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects

• Published in: European neuropsychopharmacology Vol. 23; no. 8; pp. 852 - 864
• Main Authors: Muguruza, Carolina, Moreno, José L., Umali, Adrienne, Callado, Luis F., Meana, J. Javier, González-Maeso, Javier
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2013
• Subjects: Aging; Internal Medicine; Postmortem human brain; Psychiatry; Radioligand binding; Schizophrenia; Serotonin; Serotonin 5-HT2A receptor; Suicide; Schizophrenia; Serotonin 5-HT2A receptor; Serotonin; Suicide; Radioligand binding; Postmortem human brain
• ISSN: 0924-977X; 1873-7862
• DOI: 10.1016/j.euroneuro.2012.10.006

Previous postmortem and neuroimaging studies have repeatedly suggested alterations in serotonin 5-HT2A receptor (5-HT2AR) binding associated with the pathophysiology of schizophrenia. These studies were performed with ligands, such as ketanserin, altanserin and LSD, that may bind with high-affinity...