Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model

• Published in: Stem cell research & therapy Vol. 14; no. 1; p. 135
• Main Authors: Dai, Fangfang, Wang, Ruiqi, Deng, Zhimin, Yang, Dongyong, Wang, Linlin, Wu, Mali, Hu, Wei, Cheng, Yanxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.05.2023; BioMed Central; BMC
• Subjects: Animal model; Animal models; Animals; Antigens; Apoptosis; Cancer; Cancer therapies; Chemotherapy; Chemotherapy drug; Comparative analysis; Disease Models, Animal; Drug development; Drugs; Estrogens; Female; Gene therapy; Glycoproteins; Homing behavior; Hormone replacement therapy; Hormone therapy; Humans; Immunogenicity; Immunological diseases; Immunosuppressive agents; Mesenchymal Stem Cell Transplantation - methods; Mortality; Ovaries; Pathogenesis; Polypeptides; Premature ovarian failure; Primary Ovarian Insufficiency - pathology; Reproductive status; Review; Stem cells; Tissue engineering; Transplantation; Transplantation of stem cells; Womens health; Chemotherapy drug; Animal model; Transplantation of stem cells; Hormone replacement therapy; Premature ovarian failure
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-023-03333-4

Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely related to genes, immune diseases, drugs, surgery, and psychological factors. Ideal animal models and evaluation indexes are essential for drug development and mechanism research. In our review, we firstly summarize the modeling methods of different POF animal models and compare their advantages and disadvantages. Recently, stem cells are widely studied for tumor treatment and tissue repair with low immunogenicity, high homing ability, high ability to divide and self-renew. Hence, we secondly reviewed recently published data on transplantation of stem cells in the POF animal model and analyzed the possible mechanism of their function. With the further insights of immunological and gene therapy, the combination of stem cells with other therapies should be actively explored to promote the treatment of POF in the future. Our article may provide guidance and insight for POF animal model selection and new drug development.