Sustainable production of glutathione from lignocellulose-derived sugars using engineered Saccharomyces cerevisiae

• Published in: Applied Microbiology and Biotechnology Vol. 103; no. 3; pp. 1243 - 1254
• Main Authors: Kobayashi, Jyumpei, Sasaki, Daisuke, Bamba, Takahiro, Hasunuma, Tomohisa, Kondo, Akihiko
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Science and Business Media LLC 01.02.2019; Springer Berlin Heidelberg; Springer; Springer Nature B.V
• Subjects: acids; Baking yeast; biomass; Biomedical and Life Sciences; Bioreactors; Bioreactors - microbiology; Biotechnological Products and Process Engineering; Biotechnology; Cell growth; Chemical properties; D-Xylulose Reductase; D-Xylulose Reductase - genetics; Fermentation; gene overexpression; Genes; Genetic Engineering; Genetic Engineering - methods; Genetically modified organisms; Glucose; Glucose - metabolism; Glutamate-Cysteine Ligase; Glutamate-Cysteine Ligase - genetics; Glutathione; Glutathione - biosynthesis; Glutathione Synthase; Glutathione Synthase - genetics; Industrial engineering; Life Sciences; Ligases; Lignin; Lignin - metabolism; Lignocellulose; Manufacturing costs; Manufacturing engineering; Mass production; Microbial Genetics and Genomics; Microbiology; Monosaccharides; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Alcohol Group Acceptor) - genetics; Production costs; Reductases; Saccharomyces cerevisiae; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Sugar; Sustainable production; Thiols; vector control; Xylitol; Xylitol dehydrogenase; Xylose; Xylose - metabolism; Xylose reductase; Xylulokinase; Yeast; yeasts; γ-Glutamylcysteine; D-Xylose; Aldose reductase; D-Xylose reductase; Glutathione; Xylitol dehydrogenase; Saccharomyces cerevisiae

Glutathione has diverse physiological functions, and therefore, the demand for it has increased recently. Currently, industrial mass production of glutathione is performed from D-glucose via fermentation by the budding yeast Saccharomyces cerevisiae . However, use of D-glucose often competes with de...