The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis
Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab tre...
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Published in | Journal of orthopaedic surgery and research Vol. 16; no. 1; p. 219 |
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BioMed Central Ltd
26.03.2021
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Abstract | Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis.
This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation.
BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months).
To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. |
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AbstractList | Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. Methods This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. Results BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months). Conclusion To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. Keywords: Denosumab, Finite element analysis, Pedicle screw, Loosening, Osteoporosis Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months). To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. BACKGROUNDPedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis.METHODSThis was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation.RESULTSBMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months).CONCLUSIONTo our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months). To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. Abstract Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. Methods This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. Results BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months). Conclusion To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. Methods This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. Results BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT (r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry (r = 0.35, at 24 months). Conclusion To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. Abstract Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. Methods This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment. At baseline, 12 months, and 24 months, we measured volumetric bone mineral density (BMD) using quantitative computed tomography (QCT) and performed CT-based finite element analysis (FEA). Finite element models of L4 vertebrae were created to analyze the bone strength and screw fixation. Results BMD increased with denosumab treatment. FEA revealed that both pullout strength of pedicle screws and compression force of the vertebra increased significantly at 12 and 24 months following denosumab treatment. Notably, pullout strength showed a stronger correlation with three-dimensional volumetric BMD around pedicle screw placement assessed by QCT ( r = 0.83, at 24 months) than with two-dimensional areal BMD assessed by dual energy X-ray absorptiometry ( r = 0.35, at 24 months). Conclusion To our knowledge, this is the first study to reveal that denosumab treatment achieved strong pedicle screw fixation with an increase in BMD around the screw assessed by QCT and FEA; therefore, denosumab could be useful for osteoporosis treatment during spinal surgery in elderly patients with osteoporosis. |
ArticleNumber | 219 |
Audience | Academic |
Author | Kudo, Yoshifumi Tani, Soji Oshita, Yusuke Yamamura, Ryo Nagai, Takashi Matsuoka, Akira Hayakawa, Chikara Toyone, Tomoaki Ozawa, Tomoyuki Emori, Haruka Inagaki, Katsunori Sekimizu, Masaya Ishikawa, Koji Shirahata, Toshiyuki Tsuchiya, Koki Maruyama, Hiroshi |
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Cites_doi | 10.2106/JBJS.K.00774 10.1097/BRS.0b013e31820cccfb 10.3171/2014.5.SPINE13656 10.1016/j.bone.2013.07.011 10.2106/JBJS.M.01097 10.1097/00007632-198809000-00008 10.1016/j.clinimag.2008.12.005 10.1007/s00776-014-0616-1 10.1016/j.bone.2008.08.124 10.1016/j.jbspin.2015.03.009 10.1007/s00586-018-5544-x 10.3758/bf03193146 10.3171/2010.3.SPINE09369 10.1002/jbmr.81 10.14336/AD.2014.0621 10.1097/BRS.0b013e31828826dd 10.1002/jbmr.2024 10.1016/S0142-9612(03)00556-8 10.1097/01.brs.0000261566.38422.40 10.3171/2015.1.SPINE141103 10.1299/jbse.5.499 10.1007/s00586-015-3768-6 10.1002/jbmr.5650080915 10.1016/j.injury.2015.02.011 10.1007/s00586-017-5286-1 10.1177/2192568220944169 10.1097/00007632-199712151-00002 10.1038/bmt.2012.244 10.1016/j.jos.2018.04.006 10.2147/TCRM.S123172 10.1097/00007632-199711010-00007 10.1016/S0021-9290(97)00123-1 10.1097/BRS.0000000000000540 10.1007/s00774-013-0447-8 10.1186/ar2127 10.5435/JAAOS-D-14-00042 10.1097/00007632-199411000-00008 10.1097/BSD.0000000000000703 10.7326/0003-4819-108-2-266 10.1016/S2213-8587(17)30138-9 10.1016/j.bone.2010.09.024 |
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Keywords | Osteoporosis Pedicle screw Finite element analysis Denosumab Loosening |
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References | JL Melton (2360_CR3) 1997; 22 Y Matsuura (2360_CR40) 2014; 19 Y Matsuura (2360_CR26) 2014; 39 E Seeman (2360_CR38) 2010; 25 HK Genant (2360_CR37) 2013; 56 F Faul (2360_CR20) 2007; 39 P Aspenberg (2360_CR33) 2011; 48 Y Sakai (2360_CR36) 2018; 23 M Takahata (2360_CR15) 2008; 43 TL Halvorson (2360_CR5) 1994; 19 S Adami (2360_CR39) 2012; 94 TM Keaveny (2360_CR21) 2014; 29 M Bernhardsson (2360_CR31) 2015; 46 JN Weinstein (2360_CR27) 1988; 13 TN Crotti (2360_CR32) 2004; 25 G Inoue (2360_CR12) 2014; 21 HG Bone (2360_CR17) 2017; 5 S Ohtori (2360_CR7) 2013; 38 DJ Burval (2360_CR8) 2007; 32 R Nasser (2360_CR6) 2010; 13 HK Genant (2360_CR22) 1993; 8 K Imai (2360_CR24) 2015; 6 T Hirano (2360_CR10) 1997; 22 2360_CR4 F Galbusera (2360_CR9) 2015; 24 Q Ding (2360_CR13) 2017; 26 K Ishikawa (2360_CR19) 2016; 12 JH Keyak (2360_CR25) 1997; 31 Y Kanda (2360_CR29) 2013; 48 H Makanji (2360_CR2) 2018; 27 T Morimoto (2360_CR14) 2014; 96 MK Andersson (2360_CR30) 2007; 9 S Malochet-Guinamand (2360_CR18) 2015; 82 A Atalay (2360_CR34) 2009; 33 S Soen (2360_CR41) 2013; 31 SS Rajaee (2360_CR1) 2012; 37 K Ishikawa (2360_CR11) 2018; 31 D Tawara (2360_CR35) 2010; 5 RA Lehman (2360_CR16) 2015; 23 JC Bailar (2360_CR28) 1988; 108 K Matsukawa (2360_CR23) 2015; 23 |
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issue: 5 year: 2009 ident: 2360_CR34 publication-title: Clin Imaging doi: 10.1016/j.clinimag.2008.12.005 contributor: fullname: A Atalay – volume: 19 start-page: 1012 issue: 6 year: 2014 ident: 2360_CR40 publication-title: J Orthop Sci doi: 10.1007/s00776-014-0616-1 contributor: fullname: Y Matsuura – volume: 43 start-page: 1057 issue: 6 year: 2008 ident: 2360_CR15 publication-title: Bone doi: 10.1016/j.bone.2008.08.124 contributor: fullname: M Takahata – volume: 82 start-page: 406 issue: 6 year: 2015 ident: 2360_CR18 publication-title: Jointt Bone Spine doi: 10.1016/j.jbspin.2015.03.009 contributor: fullname: S Malochet-Guinamand – volume: 27 start-page: 1868 issue: 8 year: 2018 ident: 2360_CR2 publication-title: Eur Spine J doi: 10.1007/s00586-018-5544-x contributor: fullname: H Makanji – volume: 39 start-page: 175 issue: 2 year: 2007 ident: 2360_CR20 publication-title: Behav Res Methods doi: 10.3758/bf03193146 contributor: fullname: F Faul – volume: 13 start-page: 141 year: 2010 ident: 2360_CR6 publication-title: J Neurosurg Spine doi: 10.3171/2010.3.SPINE09369 contributor: fullname: R Nasser – volume: 25 start-page: 1886 issue: 8 year: 2010 ident: 2360_CR38 publication-title: J Bone Miner Res doi: 10.1002/jbmr.81 contributor: fullname: E Seeman – volume: 6 start-page: 180 year: 2015 ident: 2360_CR24 publication-title: Aging Dis doi: 10.14336/AD.2014.0621 contributor: fullname: K Imai – volume: 38 start-page: 487 year: 2013 ident: 2360_CR7 publication-title: Spine doi: 10.1097/BRS.0b013e31828826dd contributor: fullname: S Ohtori – volume: 29 start-page: 158 issue: 1 year: 2014 ident: 2360_CR21 publication-title: J Bone Miner Res doi: 10.1002/jbmr.2024 contributor: fullname: TM Keaveny – volume: 25 start-page: 565 issue: 4 year: 2004 ident: 2360_CR32 publication-title: Biomaterials doi: 10.1016/S0142-9612(03)00556-8 contributor: fullname: TN Crotti – volume: 32 start-page: 1077 year: 2007 ident: 2360_CR8 publication-title: Spine doi: 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10.1007/s00586-017-5286-1 contributor: fullname: Q Ding – ident: 2360_CR4 doi: 10.1177/2192568220944169 – volume: 22 start-page: 2S issue: Supplement year: 1997 ident: 2360_CR3 publication-title: Spine doi: 10.1097/00007632-199712151-00002 contributor: fullname: JL Melton – volume: 48 start-page: 452 issue: 3 year: 2013 ident: 2360_CR29 publication-title: Bone Marrow Transplant doi: 10.1038/bmt.2012.244 contributor: fullname: Y Kanda – volume: 23 start-page: 734 issue: 5 year: 2018 ident: 2360_CR36 publication-title: J Orthop Sci doi: 10.1016/j.jos.2018.04.006 contributor: fullname: Y Sakai – volume: 12 start-page: 1831 year: 2016 ident: 2360_CR19 publication-title: Ther Clin Risk Manag doi: 10.2147/TCRM.S123172 contributor: fullname: K Ishikawa – volume: 22 start-page: 2504 year: 1997 ident: 2360_CR10 publication-title: Spine doi: 10.1097/00007632-199711010-00007 contributor: fullname: T Hirano – volume: 31 start-page: 125 issue: 2 year: 1997 ident: 2360_CR25 publication-title: J Biomech doi: 10.1016/S0021-9290(97)00123-1 contributor: fullname: JH Keyak – volume: 39 start-page: E1291 year: 2014 ident: 2360_CR26 publication-title: Spine doi: 10.1097/BRS.0000000000000540 contributor: fullname: Y Matsuura – volume: 31 start-page: 247 issue: 3 year: 2013 ident: 2360_CR41 publication-title: J Bone Miner Metab doi: 10.1007/s00774-013-0447-8 contributor: fullname: S Soen – volume: 9 start-page: 1 year: 2007 ident: 2360_CR30 publication-title: Arthritis Res Ther doi: 10.1186/ar2127 contributor: fullname: MK Andersson – volume: 23 start-page: 253 issue: 4 year: 2015 ident: 2360_CR16 publication-title: J Am Acad Orthop Surg doi: 10.5435/JAAOS-D-14-00042 contributor: fullname: RA Lehman – volume: 19 start-page: 2415 year: 1994 ident: 2360_CR5 publication-title: Spine doi: 10.1097/00007632-199411000-00008 contributor: fullname: TL Halvorson – volume: 31 start-page: E473 issue: 9 year: 2018 ident: 2360_CR11 publication-title: Clin Spine Surg doi: 10.1097/BSD.0000000000000703 contributor: fullname: K Ishikawa – volume: 108 start-page: 266 issue: 2 year: 1988 ident: 2360_CR28 publication-title: Ann Intern Med doi: 10.7326/0003-4819-108-2-266 contributor: fullname: JC Bailar – volume: 5 start-page: 513 issue: 7 year: 2017 ident: 2360_CR17 publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(17)30138-9 contributor: fullname: HG Bone – volume: 48 start-page: 225 issue: 2 year: 2011 ident: 2360_CR33 publication-title: Bone doi: 10.1016/j.bone.2010.09.024 contributor: fullname: P Aspenberg |
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Snippet | Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment... Abstract Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a... Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising... BACKGROUNDPedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising... Abstract Background Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a... |
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SubjectTerms | Age Factors Aged Analysis Back surgery Bone Density Bone implants Bone mineral density Bone strength Bones Care and treatment Compression Computed tomography Denosumab Denosumab - therapeutic use Density Dual energy X-ray absorptiometry Finite Element Analysis Finite element method Fractures Humans Longitudinal Studies Loosening Lumbar Vertebrae - surgery Mathematical models Monoclonal antibodies Orthopedic surgery Orthopedics Osteoporosis Osteoporosis, Postmenopausal - drug therapy Osteoporosis, Postmenopausal - metabolism Patients Pedicle screw Pedicle Screws - adverse effects Post-menopause Postmenopausal women Prospective Studies Prosthesis Failure - adverse effects Software Spinal Fusion - adverse effects Spinal Fusion - methods Spine Surgeons Surgery Thoracic Vertebrae - surgery Time Factors Titanium alloys Tomography, X-Ray Computed - methods Treatment Outcome Vertebrae Yield stress |
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Title | The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis |
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