Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

• Published in: Molecular cancer Vol. 21; no. 1; pp. 207 - 26
• Main Authors: Han, Qing-Fang, Li, Wen-Jia, Hu, Kai-Shun, Gao, Jie, Zhai, Wen-Long, Yang, Jing-Hua, Zhang, Shui-Jun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.11.2022; BioMed Central; BMC
• Subjects: Biogenesis; Biosynthesis; Cancer; Cell Communication; Cell Membrane - metabolism; Development and progression; Exosomes; Exosomes - metabolism; Gene expression; Growth factors; Health aspects; Heparan sulfate; Humans; Implications; Kinases; Lipids; Membrane fusion; Multivesicular Bodies - metabolism; Neoplasms - metabolism; Physiological aspects; Plasma; Proteins; Regulation; Review; Regulation; Biogenesis; Exosomes; Cancer; Implications

Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their biogenesis involves four key steps, including cargo sorting, MVB formation and maturation, transport of MVBs, and MVB fusion with the plasma membrane. Each p...