Establishment of a Human Cell Line Secreting Neuron‐specific Enolase from a Primitive Neuroectodermal Tumor of the Retroperitoneal Cavity

• Published in: Cancer science Vol. 86; no. 12; pp. 1172 - 1178
• Main Authors: Nakashima, Jun, Horiguchi, Yutaka, Ueno, Munehisa, Nakamura, Kaoru, Tachibana, Masaaki, Hata, Jun‐ichi, Tazaki, Hiroshi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1995; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: Adult; Aneuploidy; Animals; Biological and medical sciences; Biomarkers, Tumor - metabolism; Cell culture; Cell differentiation; Chromosome Aberrations; Electron microscopy; Fatal Outcome; Genes, myc; Histogenesis; Humans; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kidneys; Male; Medical sciences; Mice; Mice, Nude; Myc protein; Neoplasm Proteins - metabolism; Neoplasm Transplantation; Nephrology. Urinary tract diseases; Nervous system diseases; Neural crest; Neuroectodermal Tumors - genetics; Neuroectodermal Tumors - metabolism; Neuroectodermal Tumors - pathology; Neuron‐specific enolase; Nude mice; Phosphopyruvate hydratase; Phosphopyruvate Hydratase - metabolism; Primitive neuroectodermal tumor; Serum levels; Tumor Cells, Cultured; Tumorigenesis; Tumors of the urinary system; Xenografts; Human; Cell culture; Retroperitoneal; Enzyme; Rodentia; Tissue specificity; Exploration; Lyases; Tumorigenicity; Retroperitoneal disease; Malignant tumor; Neuroectodermal tumor; Pathology; Vertebrata; Mammalia; Neuron; Mouse; Animal; Established cell line; Cytogenetics; Carbon-oxygen lyases; Phosphopyruvate hydratase; Hydro-lyases

Primitive neuroectodermal tumor (PNET) is one of the small round cell malignancies of presumed neural crest origin for which an effective treatment has not yet been established. In the present study, a human cell line, designated KU‐9, was established from a 27‐year‐old male patient with PNET of the...