Catalytic CH Bond Addition of Pyridines to Allenes by a Rare-Earth Catalyst

• Published in: Chemistry : a European journal Vol. 21; no. 23; pp. 8394 - 8398
• Main Authors: Song, Guoyong, Wang, Baoli, Nishiura, Masayoshi, Hou, Zhaomin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.06.2015; WILEY‐VCH Verlag; Wiley
• Subjects: alkenylation; allenes; Bonding; Catalysis; Catalysts; Cationic; Chemistry; Chemistry, Multidisciplinary; CH addition; Derivatives; Physical Sciences; Pyridines; Rare earth metals; Scandium; Science & Technology; ACTIVATION; ALKYL; COMPLEXES; REACTIVITY; scandium; POLYMERIZATION; SELECTIVE ALKENYLATION; ALLYLATIONS; alkenylation; allenes; pyridines; C-H addition; INSERTION REACTIONS; COPOLYMERIZATION; DERIVATIVES; CH addition

The catalytic CH addition of pyridines to allenes has been achieved for the first time by using a half‐sandwich scandium catalyst, thus constituting a straightforward and atom‐economical route for the synthesis of alkenylated pyridine derivatives. The reaction proceeded regio‐ and stereoselectively...