Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

• Published in: Journal of investigative dermatology Vol. 135; no. 12; pp. 3001 - 3008
• Main Authors: Ando, Noriko, Nakamura, Yuki, Aoki, Rui, Ishimaru, Kayoko, Ogawa, Hideoki, Okumura, Ko, Shibata, Shigenobu, Shimada, Shinji, Nakao, Atsuhito
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015; Elsevier Limited; Nature Publishing Group
• Subjects: Aminoquinolines - pharmacology; Animals; Circadian Rhythm; CLOCK Proteins - genetics; CLOCK Proteins - physiology; Dermatitis - etiology; Dermatitis - genetics; Dermatitis - immunology; Female; Interleukin-23 - physiology; Mice; Mice, Inbred C57BL; Mutation; Original; Period Circadian Proteins - genetics; Psoriasis - etiology; Psoriasis - genetics; Psoriasis - immunology; Receptors, Antigen, T-Cell, gamma-delta - analysis; T-Lymphocytes - immunology

There are several reports suggesting that the pathophysiology of psoriasis may be associated with aberrant circadian rhythms. However, the mechanistic link between psoriasis and the circadian time-keeping system, “the circadian clock,” remains unclear. This study determined whether the core circadia...