Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting

• Published in: BMC infectious diseases Vol. 20; no. 1; p. 130
• Main Authors: Hoel, Ida Marie, Sviland, Lisbet, Syre, Heidi, Dyrhol-Riise, Anne Ma, Skarstein, Ingerid, Jebsen, Peter, Jørstad, Melissa Davidsen, Wiker, Harald, Mustafa, Tehmina
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.02.2020; BioMed Central; BMC
• Subjects: Adult; Antigen detection test; Antigens; Antigens, Bacterial - immunology; Biomedical laboratories; Biopsy, Fine-Needle; Diagnosis; Diagnostic systems; Diagnostic test; Diagnostic tests; Disease; Diseases; Extrapulmonary tuberculosis; Female; Fluids; Formaldehyde; High income; Hospitals; Humans; Immunoassay; Immunochemistry; Immunohistochemistry; Immunologic Tests - methods; Income; Infectious diseases; Laboratories; Lymphatic system; Male; Measurement; Methods; Microbiology; Microscopy; Middle Aged; MPT64; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - pathogenicity; Norway - epidemiology; Pathology; Physiological aspects; Polymerase Chain Reaction; Prevalence; Sensitivity; Sensitivity and Specificity; Setting (Literature); Studies; Tuberculosis; Tuberculosis - diagnosis; Tuberculosis - epidemiology; Norway; United States > US; Immunohistochemistry; Extrapulmonary tuberculosis; Diagnostic test; Antigen detection test; MPT64

Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the paucibacillary nature of the disease. The immunochemistry-based MPT64 antigen detection test (MPT64 test) has shown promising results for diagnosing EPTB in previous studies performed in low-resource settings, with higher sens...