Cerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects

• Published in: Behavioural brain research Vol. 281; pp. 187 - 198
• Main Authors: Bogdanov, Volodymyr B., Viganò, Alessandro, Noirhomme, Quentin, Bogdanova, Olena V., Guy, Nathalie, Laureys, Steven, Renshaw, Perry F., Dallel, Radhouane, Phillips, Christophe, Schoenen, Jean
• Format: Journal Article Web Resource
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2015; Elsevier; Elsevier Science
• Subjects: Adult; Brain imaging; Brain Mapping - methods; Cerebral Cortex - physiopathology; Cold Temperature; Conditioned pain modulation; Conditioning (Psychology); Female; Healthy Volunteers; Hot Temperature; Human health sciences; Humans; Individuality; Life Sciences; Magnetic Resonance Imaging; Middle Aged; Neurologie; Neurology; Neurons and Cognition; Pain - physiopathology; Pain - psychology; Pain Measurement - methods; Pain Threshold; Prefrontal cortex; Prefrontal Cortex - physiopathology; Sciences de la santé humaine; Young Adult; ACC; Brain imaging; SMA; Prefrontal cortex; PFC; Conditioned pain modulation; OFC; NRS; fMRI; VOI; PAG; BOLD; SI and SII; FWER; noxious inhibitory control; tension-type headache; perception; connectivity; placebo analgesia; cold pressor challenge; brain response; activation; periaqueductal gray; stimulation

•The mechanisms underlying conditioned pain modulation are multifaceted.•During cold, application-specific cerebral activations were found in precuneus and left insula.•Conditioned suppression of insula test-pain response was related to hypoalgesia.•The insular changes are predicted by early prefron...