Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis

• Published in: Stem cell research & therapy Vol. 12; no. 1; pp. 20 - 17
• Main Authors: Cao, Yong, Xu, Yan, Chen, Chunyuan, Xie, Hui, Lu, Hongbin, Hu, Jianzhong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.01.2021; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Angiogenesis; Angiopoietin-like protein 3; Biotechnology; Blood-brain barrier; Cord blood; Exosome; Exosomes; Health aspects; Human urine stem cell; Hydrogels; Injection; Laboratories; Proteins; Reagents; Recovery of function; Signal transduction; Spinal cord; Spinal cord injuries; Spinal cord injury; Stem cells; Transmission electron microscopy; Transplantation; Urine; United Kingdom > UK; United States > US; China; Japan; Angiogenesis; Human urine stem cell; Spinal cord injury; Exosome; Angiopoietin-like protein 3

Spinal cord injury is a devastating clinical condition for which there are currently no effective therapeutic options. In the present study, we aim to investigate if the effect of an administered injection of exosomes derived from human urine stem cell (USC-Exo) embedded in hydrogel could improve th...