Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 2673 - 2684
• Main Authors: Rosenke, Kyle, Meade-White, Kimberly, Letko, Michael, Clancy, Chad, Hansen, Frederick, Liu, Yanan, Okumura, Atsushi, Tang-Huau, Tsing-Lee, Li, Rong, Saturday, Greg, Feldmann, Friederike, Scott, Dana, Wang, Zhongde, Munster, Vincent, Jarvis, Michael A., Feldmann, Heinz
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Animals; Chlorocebus aethiops; Coronaviruses; COVID-19; COVID-19 - etiology; COVID-19 - immunology; COVID-19 - pathology; Cricetinae; Disease Models, Animal; Disease Susceptibility; Female; hamster; infection model; Infections; Lung - pathology; Male; Mesocricetus; pneumonia; Receptors, Interleukin-2 - physiology; RNA, Viral - analysis; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - metabolism; susceptible; Vero Cells; SARS-CoV-2; infection model; pneumonia; hamster; susceptible

Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide. There is currently no approved vaccine to halt the spread of SARS-CoV-2 and only very few treatment options are available to man...