Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

• Published in: Nature communications Vol. 12; no. 1; p. 1510
• Main Authors: Kupari, Jussi, Usoskin, Dmitry, Parisien, Marc, Lou, Daohua, Hu, Yizhou, Fatt, Michael, Lönnerberg, Peter, Spångberg, Mats, Eriksson, Bengt, Barkas, Nikolaos, Kharchenko, Peter V., Loré, Karin, Khoury, Samar, Diatchenko, Luda, Ernfors, Patrik
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 14/32; 38/43; 38/91; 49/39; 631/337/2019; 631/378/1959/2605; 631/378/2620/410/2610; 692/308/2056; Animals; Chronic pain; Chronic Pain - genetics; Chronic Pain - metabolism; Convergence; Dorsal root ganglia; Female; Ganglia, Spinal; Gene Expression; Genomes; Heritability; Humanities and Social Sciences; Humans; Learning algorithms; Macaca mulatta; Machine learning; Male; Medicin och hälsovetenskap; Mice; multidisciplinary; Neurons; Pain; Primates; Science; Science (multidisciplinary); Sensory neurons; Sensory Receptor Cells - metabolism; Transcriptome; Transcriptomes; Uniqueness; Wildlife conservation

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to chronic pain. Identification of primate sensory neuron types is critical for understanding the cellular origin and heritability of chronic pain. However, molecular insights into the primate sensory neurons are mi...