Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients
To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Prospective cross-sectional study. SS dry eye patie...
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| Published in | American journal of ophthalmology Vol. 156; no. 2; pp. 247 - 253.e1 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.08.2013
Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated.
Prospective cross-sectional study.
SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients.
All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = −0.22, P = .012) and Schirmer I test (R = −0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = −0.38, P = .02) in the non-SS group.
Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. |
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| AbstractList | To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated.
Prospective cross-sectional study.
SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients.
All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = −0.22, P = .012) and Schirmer I test (R = −0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = −0.38, P = .02) in the non-SS group.
Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design Prospective cross-sectional study. Methods SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon ? (IFN-?), and tumor necrosis factor ? (TNF-?) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-?, and IL-6 were significantly different among the 3 groups (IL-17: SS > controlP< .001, non-SS > controlP= .042, SS > non-SSP< .001; TNF-?: SS > controlP= .006, non-SS > controlP= .034, SS > non-SSP= .029; IL-6: SS > controlP= .002, non-SS > controlP= .032, SS > non-SSP= .002). IL-17 was significantly correlated with TBUT (R = ?0.22,P= .012) and Schirmer I test (R = ?0.36,P= .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = ?0.38,P= .02) in the non-SS group. Conclusions Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design Prospective cross-sectional study. Methods SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = −0.22, P = .012) and Schirmer I test (R = −0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = −0.38, P = .02) in the non-SS group. Conclusions Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated.PURPOSETo compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated.Prospective cross-sectional study.DESIGNProspective cross-sectional study.SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients.METHODSSS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients.All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group.RESULTSAll cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group.Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.CONCLUSIONSDifferences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjogren syndrome (SS) dry eye, non-Sjogren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Design Prospective cross-sectional study. Methods SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon gamma (IFN- gamma ), and tumor necrosis factor alpha (TNF- alpha ) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. Results All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF- alpha , and IL-6 were significantly different among the 3 groups (IL-17: SS > control < .001, non-SS > control = .042, SS > non-SS < .001; TNF- alpha : SS > control = .006, non-SS > control = .034, SS > non-SS = .029; IL-6: SS > control = .002, non-SS > control = .032, SS > non-SS = .002). IL-17 was significantly correlated with TBUT (R = -0.22, = .012) and Schirmer I test (R = -0.36, = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, = .02) in the non-SS group. Conclusions Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. Prospective cross-sectional study. SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-α, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-α: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome. |
| Author | Nam, Sang Min Ahn, Ji Min Yoon, Sang Chul Kim, Eung Kweon Seo, Kyoung Yul Kim, Tae-Im Lee, Sang Yeop Han, Soo Jung |
| Author_xml | – sequence: 1 givenname: Sang Yeop surname: Lee fullname: Lee, Sang Yeop organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea – sequence: 2 givenname: Soo Jung surname: Han fullname: Han, Soo Jung organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea – sequence: 3 givenname: Sang Min surname: Nam fullname: Nam, Sang Min organization: Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi, South Korea – sequence: 4 givenname: Sang Chul surname: Yoon fullname: Yoon, Sang Chul organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea – sequence: 5 givenname: Ji Min surname: Ahn fullname: Ahn, Ji Min organization: Siloam Eye Hospital, Seoul, South Korea – sequence: 6 givenname: Tae-Im surname: Kim fullname: Kim, Tae-Im organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea – sequence: 7 givenname: Eung Kweon surname: Kim fullname: Kim, Eung Kweon organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea – sequence: 8 givenname: Kyoung Yul surname: Seo fullname: Seo, Kyoung Yul email: seoky@yuhs.ac organization: Institute of Vision Research, Department of Ophthalmology, Severance Eye and ENT Hospital. Yonsei University College of Medicine, Seoul, South Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23752063$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2013 Elsevier Inc. Elsevier Inc. Copyright © 2013 Elsevier Inc. All rights reserved. Copyright Elsevier Limited Aug 2013 |
| Copyright_xml | – notice: 2013 Elsevier Inc. – notice: Elsevier Inc. – notice: Copyright © 2013 Elsevier Inc. All rights reserved. – notice: Copyright Elsevier Limited Aug 2013 |
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| DOI | 10.1016/j.ajo.2013.04.003 |
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| Snippet | To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal subjects.... Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non–Sjögren syndrome (non-SS) dry eye, and normal... To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal subjects.... Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjögren syndrome (SS) dry eye, non-Sjögren syndrome (non-SS) dry eye, and normal... Purpose To compare concentrations of tear cytokines in 3 groups composed of Sjogren syndrome (SS) dry eye, non-Sjogren syndrome (non-SS) dry eye, and normal... |
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| SubjectTerms | Adult Aged Cross-Sectional Studies Cytokines Cytokines - metabolism Eye care products Eye Proteins - metabolism Female Humans Immunoassay Medical research Middle Aged Ophthalmology Prospective Studies Sjogren's Syndrome - diagnosis Sjogren's Syndrome - metabolism Studies Tears - chemistry Tears - metabolism |
| Title | Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients |
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