Vulnerability of welders to manganese exposure – A neuroimaging study

• Published in: Neurotoxicology (Park Forest South) Vol. 45; pp. 285 - 292
• Main Authors: Long, Zaiyang, Jiang, Yue-Ming, Li, Xiang-Rong, Fadel, William, Xu, Jun, Yeh, Chien-Lin, Long, Li-Ling, Luo, Hai-Lan, Harezlak, Jaroslaw, Murdoch, James B., Zheng, Wei, Dydak, Ulrike
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2014
• Subjects: Adult; Air Pollutants, Occupational - analysis; Air Pollutants, Occupational - metabolism; Brain Chemistry; Erythrocytes - chemistry; Frontal cortex; Humans; Magnetic Resonance Imaging; Magnetic resonance spectroscopy; Male; Manganese - metabolism; Manganese - urine; Manganese neurotoxicity; Manganese Poisoning - metabolism; Middle Aged; Occupational Exposure; Particle Size; Smelting; Welding; Magnetic resonance spectroscopy; Frontal cortex; Magnetic resonance imaging; Welding; Smelting; Manganese neurotoxicity

•In vivo brain metabolism and Mn deposition were explored in Mn-exposed workers.•Two occupational settings were compared: smelting and welding.•The frontal cortex shows the most pronounced metabolic changes.•The results suggest that welders are more susceptible to Mn-induced neurotoxicity. Increased...