Eight-gene metabolic signature related with tumor-associated macrophages predicting overall survival for hepatocellular carcinoma

• Published in: BMC cancer Vol. 21; no. 1; pp. 31 - 15
• Main Authors: Huo, Junyu, Wu, Liqun, Zang, Yunjin, Dong, Hongjing, Liu, Xiaoqiang, He, Fu, Zhang, Xiao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.01.2021; BioMed Central; BMC
• Subjects: Abundance; Aged; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Cellular Reprogramming - genetics; Correlation analysis; CTLA-4 protein; Datasets; Female; Follow-Up Studies; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomes; Health aspects; Hepatocellular carcinoma; Hepatoma; Humans; Immune checkpoint; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Macrophages; Male; Medical prognosis; Metabolic; Metabolic regulation; Metabolism; Metabolites; Metastases; Metastasis; Patients; PD-1 protein; Prognosis; Prognostic; Regression analysis; Risk groups; Signature; Solid tumors; Survival analysis; Survival Rate; Tumor-associated macrophages; Tumor-Associated Macrophages - metabolism; Tumor-Associated Macrophages - pathology; Tumors; China; Hepatocellular carcinoma; Metabolic; Prognostic; Tumor-associated macrophages; Signature

In recent years, the relationship between tumor-associated macrophages (TAMs) and solid tumors has become a research hotspot. This study aims to explore the close relationship of TAMs with metabolic reprogramming genes in hepatocellular carcinoma (HCC) to provide new methods of treatment for HCC. Th...