Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis

• Published in: BMC infectious diseases Vol. 17; no. 1; pp. 279 - 13
• Main Authors: Zilberberg, Marya D., Nathanson, Brian H., Sulham, Kate, Fan, Weihong, Shorr, Andrew F.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.04.2017; BioMed Central; BMC
• Subjects: Adult; Adults; Age; Aged; Aged, 80 and over; Analysis; Anti-Bacterial Agents - economics; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Antimicrobial resistance; Audio frequencies; Bacilli; Bacteria; Bacterial pneumonia; Biometrics; Carbapenems; Carbapenems - economics; Carbapenems - therapeutic use; Care and treatment; Cephalosporins; Children; Citrobacter; Classification; Clinical isolates; Communities; CRE bacteria; Cystic fibrosis; Death; Diagnosis; Disease control; Disorders; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Bacterial; E coli; Enterobacteriaceae; Enterobacteriaceae infections; Enterobacteriaceae Infections - drug therapy; Enterobacteriaceae Infections - economics; Enterobacteriaceae Infections - epidemiology; Epidemiology; Ertapenem; Female; Health Care Costs; Health risks; Hemodialysis; Hospital Mortality; Hospitalization; Hospitalization - economics; Hospitalization - statistics & numerical data; Humans; Inappropriate empiric therapy; Inappropriate Prescribing - economics; Inappropriate Prescribing - statistics & numerical data; Infectious diseases; Laboratories; Length of Stay - economics; Male; Microbiology; Middle Aged; Minimum inhibitory concentration; Mortality risk; Pathogens; Patient outcomes; Patients; Pneumonia; Pneumonia - drug therapy; Pneumonia - economics; Pneumonia - epidemiology; Pneumonia - microbiology; Preservation; Prevalence; Respiratory failure; Retrospective Studies; Risk; Risk Factors; Sepsis; Sepsis - drug therapy; Sepsis - economics; Sepsis - epidemiology; Sepsis - microbiology; Staphylococcus infections; Studies; Surveillance; Therapy; Treatment Outcome; Trends; Urinary tract; Urinary tract diseases; Urinary tract infections; Urinary Tract Infections - drug therapy; Urinary Tract Infections - economics; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; Urogenital system; UTI; United States; United States > US; Hospital cost; Hospital mortality; Pneumonia; Sepsis; Antimicrobial resistance; UTI; Inappropriate empiric therapy; Enterobacteriaceae

Drug resistance among gram-negative pathogens is a risk factor for inappropriate empiric treatment (IET), which in turn increases the risk for mortality. We explored the impact of carbapenem-resistant Enterobacteriaceae (CRE) on the risk of IET and of IET on outcomes in patients with Enterobacteriac...