POstmastectomy radioThErapy in Node-posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a study protocol for a multicenter prospective phase III randomized controlled trial

• Published in: BMC cancer Vol. 21; no. 1; pp. 1185 - 10
• Main Authors: Zhao, Xu-Ran, Fang, Hui, Tang, Yu, Hu, Zhi-Hui, Jing, Hao, Liang, Lin, Yan, Xue-Na, Song, Yong-Wen, Jin, Jing, Liu, Yue-Ping, Chen, Bo, Tang, Yuan, Qi, Shu-Nan, Li, Ning, Lu, Ning-Ning, Men, Kuo, Hu, Chen, Zhang, Yu-Hui, Li, Ye-Xiong, Wang, Shu-Lian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.11.2021; BioMed Central; BMC
• Subjects: Anthracycline; Anthracyclines - therapeutic use; Antineoplastic Agents - therapeutic use; Axilla; Biopsy; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Breast Neoplasms - radiotherapy; Breast Neoplasms - therapy; Bridged-Ring Compounds - therapeutic use; Cancer therapies; Cardiovascular disease; Care and treatment; Chemotherapy; Clinical trials; Clinical Trials, Phase III as Topic; Computed tomography; Disease-Free Survival; Dissection; Dose Fractionation, Radiation; Drug dosages; Female; Heart; Humans; Internal mammary node irradiation; Lymphatic Irradiation; Lymphatic Metastasis - diagnostic imaging; Lymphatic Metastasis - radiotherapy; Lymphatic system; Magnetic resonance imaging; Mammography; Mastectomy; Metastasis; Multicenter Studies as Topic; Patient outcomes; Patients; Population studies; Postmastectomy radiotherapy; Postoperative care; Postoperative Care - methods; Prospective Studies; Quality assurance; Radiation therapy; Radiotherapy; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal - methods; Randomized Controlled Trials as Topic; Skin cancer; Study Protocol; Survival; Survival outcome; Taxoids - therapeutic use; Testing; Thyroid gland; Tomography, X-Ray Computed; Toxicity; Tumors; Ultrasonic imaging; China; Breast cancer; Postmastectomy radiotherapy; Toxicity; Survival outcome; Internal mammary node irradiation

Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer. Controversy exists as to whether the internal mammary node (IMN) region is an essential...